FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158652275> ?p ?o ?g. }

• W3158652275 endingPage "1898" @default.
• W3158652275 startingPage "1885" @default.
• W3158652275 abstract "Leishmaniasis is caused by an obligate intracellular protozoan parasite. The clinical forms of leishmaniasis differ from cutaneous leishmaniasis, mucocutaneous leishmaniasis and visceral leishmaniasis (VL) which depend on the parasite species and the host's immune responses. There are significant challenges to the available anti-leishmanial drug therapy, particularly in severe forms of disease, and the rise of drug resistance has made it more difficult. Currently, no licensed vaccines have been introduced to the market for the control and elimination of VL. A potential target for use in candidate vaccines against leishmaniasis has been shown to be leishmania Kinetoplastid membrane protein-11 (KMP-11) antigen. In this study, we chose KMP-11 antigen as target antigen in our vaccine construct. In addition, B-type flagellin (fliC) was used as an adjuvant for enhancing vaccine immunogenicity. The GSGSGSGSGSG linker was applied to link the KMP-11 antigen and fliC (KMP-11-fliC) to construct our fusion protein. Bioinformatics approaches such as; 3D homology modeling, CTL, B-cell, MHC class I and II epitopes prediction, allergenicity, antigenicity evaluations, molecular docking, fast simulations of flexibility of docked complex and in silico cloning were employed to analysis and evaluation of various properties of the designed fusion construct. Computational results showed that our engineered structure has the potential for proper stimulation of cellular and humoral immune responses against VL. Consequently, it could be proposed as a candidate vaccine against VL according to these data and after verifying the efficacy of the candidate vaccine through in vivo and in vitro immunological tests." @default.
• W3158652275 created "2021-05-10" @default.
• W3158652275 creator A5041001399 @default.
• W3158652275 creator A5063283187 @default.
• W3158652275 creator A5072315322 @default.
• W3158652275 creator A5082456973 @default.
• W3158652275 date "2021-04-24" @default.
• W3158652275 modified "2023-09-27" @default.
• W3158652275 title "Designing of a Novel Fusion Protein Vaccine Candidate Against Human Visceral Leishmaniasis (VL) Using Immunoinformatics and Structural Approaches" @default.
• W3158652275 cites W1223371859 @default.
• W3158652275 cites W1490664191 @default.
• W3158652275 cites W1646413467 @default.
• W3158652275 cites W1676233161 @default.
• W3158652275 cites W1898151446 @default.
• W3158652275 cites W1925706971 @default.
• W3158652275 cites W1987534870 @default.
• W3158652275 cites W1992192767 @default.
• W3158652275 cites W1993321098 @default.
• W3158652275 cites W1995127073 @default.
• W3158652275 cites W2012625502 @default.
• W3158652275 cites W2013383836 @default.
• W3158652275 cites W2020719323 @default.
• W3158652275 cites W2022113931 @default.
• W3158652275 cites W2035014358 @default.
• W3158652275 cites W2037312364 @default.
• W3158652275 cites W2046144222 @default.
• W3158652275 cites W2046793259 @default.
• W3158652275 cites W2050717189 @default.
• W3158652275 cites W2071258810 @default.
• W3158652275 cites W2074986801 @default.
• W3158652275 cites W2081955017 @default.
• W3158652275 cites W2090928701 @default.
• W3158652275 cites W2096495474 @default.
• W3158652275 cites W2097874743 @default.
• W3158652275 cites W2100316154 @default.
• W3158652275 cites W2102023232 @default.
• W3158652275 cites W2102993309 @default.
• W3158652275 cites W2110474492 @default.
• W3158652275 cites W2112968886 @default.
• W3158652275 cites W2125038701 @default.
• W3158652275 cites W2127331245 @default.
• W3158652275 cites W2127635589 @default.
• W3158652275 cites W2144887013 @default.
• W3158652275 cites W2152769327 @default.
• W3158652275 cites W2159591337 @default.
• W3158652275 cites W2168036974 @default.
• W3158652275 cites W2233559386 @default.
• W3158652275 cites W2271914738 @default.
• W3158652275 cites W2385321340 @default.
• W3158652275 cites W2467440148 @default.
• W3158652275 cites W2481985723 @default.
• W3158652275 cites W2490526398 @default.
• W3158652275 cites W2549976854 @default.
• W3158652275 cites W2744401611 @default.
• W3158652275 cites W2753696621 @default.
• W3158652275 cites W2775643792 @default.
• W3158652275 cites W2777159454 @default.
• W3158652275 cites W2783102765 @default.
• W3158652275 cites W2789392477 @default.
• W3158652275 cites W2802442447 @default.
• W3158652275 cites W2884928752 @default.
• W3158652275 cites W2889205678 @default.
• W3158652275 cites W2903490844 @default.
• W3158652275 cites W2908898351 @default.
• W3158652275 cites W2933573917 @default.
• W3158652275 cites W2941112903 @default.
• W3158652275 cites W2941222865 @default.
• W3158652275 cites W2984380652 @default.
• W3158652275 cites W3007680806 @default.
• W3158652275 cites W3012239334 @default.
• W3158652275 cites W3016922254 @default.
• W3158652275 cites W3026418306 @default.
• W3158652275 cites W3039736155 @default.
• W3158652275 cites W3039821298 @default.
• W3158652275 cites W3047978315 @default.
• W3158652275 cites W3082799465 @default.
• W3158652275 cites W3099088600 @default.
• W3158652275 cites W3106776664 @default.
• W3158652275 cites W4211261243 @default.
• W3158652275 cites W4242478859 @default.
• W3158652275 cites W802042704 @default.
• W3158652275 doi "https://doi.org/10.1007/s10989-021-10218-8" @default.
• W3158652275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8067785" @default.
• W3158652275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33935610" @default.
• W3158652275 hasPublicationYear "2021" @default.
• W3158652275 type Work @default.
• W3158652275 sameAs 3158652275 @default.
• W3158652275 citedByCount "6" @default.
• W3158652275 countsByYear W31586522752021 @default.
• W3158652275 countsByYear W31586522752022 @default.
• W3158652275 countsByYear W31586522752023 @default.
• W3158652275 crossrefType "journal-article" @default.
• W3158652275 hasAuthorship W3158652275A5041001399 @default.
• W3158652275 hasAuthorship W3158652275A5063283187 @default.
• W3158652275 hasAuthorship W3158652275A5072315322 @default.
• W3158652275 hasAuthorship W3158652275A5082456973 @default.
• W3158652275 hasBestOaLocation W31586522751 @default.
• W3158652275 hasConcept C147483822 @default.

• next