FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158676299> ?p ?o ?g. }

• W3158676299 abstract "Abstract Adaptive immunity relies on T lymphocytes that use αβ T-cell receptors (TCRs) to discriminate amongst peptides presented by MHC molecules (pMHCs). An enhanced ability to screen for pMHCs capable of inducing robust T-cell responses could have broad applications in diagnosing and treating immune diseases. T-cell activation in vivo relies on biomechanical forces to trigger activation by sparse antigenic pMHCs. However, in vitro screening tests potential pMHCs without force and at high (non-physiological) pMHC densities and thus often fails to predict potent agonists in vivo . Here, we present a technology that uses biomechanical force to initiate T-cell triggering in high throughput. BATTLES (Biomechanically-Assisted T-cell Triggering for Large-scale Exogenous-pMHC Screening) displays candidate pMHCs on spectrally encoded ‘smart beads’ capable of applying physiological loads to T cells, facilitating exploration of the force- and sequence-dependent landscape of T-cell responses. BATTLES can be used to explore basic T-cell mechanobiology and T cell-based immunotherapies." @default.
• W3158676299 created "2021-05-10" @default.
• W3158676299 creator A5073719214 @default.
• W3158676299 date "2021-07-21" @default.
• W3158676299 modified "2023-09-27" @default.
• W3158676299 title "Structure-activity mapping of the peptide- and force-dependent landscape of T-cell activation" @default.
• W3158676299 cites W1537355572 @default.
• W3158676299 cites W1567219703 @default.
• W3158676299 cites W1582904613 @default.
• W3158676299 cites W1670817326 @default.
• W3158676299 cites W1966474647 @default.
• W3158676299 cites W1966901825 @default.
• W3158676299 cites W1967359088 @default.
• W3158676299 cites W1969000493 @default.
• W3158676299 cites W1974494916 @default.
• W3158676299 cites W1975503309 @default.
• W3158676299 cites W1979731533 @default.
• W3158676299 cites W1989199118 @default.
• W3158676299 cites W1992699522 @default.
• W3158676299 cites W1993238707 @default.
• W3158676299 cites W1993369787 @default.
• W3158676299 cites W1995028380 @default.
• W3158676299 cites W2007271955 @default.
• W3158676299 cites W2011584482 @default.
• W3158676299 cites W2012826756 @default.
• W3158676299 cites W2021673674 @default.
• W3158676299 cites W2032717102 @default.
• W3158676299 cites W2042704418 @default.
• W3158676299 cites W2061394685 @default.
• W3158676299 cites W2064253793 @default.
• W3158676299 cites W2074545819 @default.
• W3158676299 cites W2082103058 @default.
• W3158676299 cites W2096234619 @default.
• W3158676299 cites W2123590972 @default.
• W3158676299 cites W2128473599 @default.
• W3158676299 cites W2128685355 @default.
• W3158676299 cites W2131185370 @default.
• W3158676299 cites W2133240422 @default.
• W3158676299 cites W2133745988 @default.
• W3158676299 cites W2135707882 @default.
• W3158676299 cites W2145847351 @default.
• W3158676299 cites W2152645204 @default.
• W3158676299 cites W2160420489 @default.
• W3158676299 cites W2226528870 @default.
• W3158676299 cites W2265605294 @default.
• W3158676299 cites W2280722998 @default.
• W3158676299 cites W2345768994 @default.
• W3158676299 cites W2347077379 @default.
• W3158676299 cites W2417253274 @default.
• W3158676299 cites W2507608410 @default.
• W3158676299 cites W2536043437 @default.
• W3158676299 cites W2558984237 @default.
• W3158676299 cites W2668309208 @default.
• W3158676299 cites W2741797758 @default.
• W3158676299 cites W2748062037 @default.
• W3158676299 cites W2760071615 @default.
• W3158676299 cites W2808157488 @default.
• W3158676299 cites W2810745017 @default.
• W3158676299 cites W2884809460 @default.
• W3158676299 cites W2898885920 @default.
• W3158676299 cites W2899327929 @default.
• W3158676299 cites W2901423492 @default.
• W3158676299 cites W2911644242 @default.
• W3158676299 cites W2912257772 @default.
• W3158676299 cites W2950122329 @default.
• W3158676299 cites W2968849363 @default.
• W3158676299 cites W2972125851 @default.
• W3158676299 cites W3010883635 @default.
• W3158676299 cites W3029644242 @default.
• W3158676299 cites W3108618435 @default.
• W3158676299 cites W3109882742 @default.
• W3158676299 doi "https://doi.org/10.21203/rs.3.rs-636850/v1" @default.
• W3158676299 hasPublicationYear "2021" @default.
• W3158676299 type Work @default.
• W3158676299 sameAs 3158676299 @default.
• W3158676299 citedByCount "0" @default.
• W3158676299 crossrefType "posted-content" @default.
• W3158676299 hasAuthorship W3158676299A5073719214 @default.
• W3158676299 hasBestOaLocation W31586762991 @default.
• W3158676299 hasConcept C1491633281 @default.
• W3158676299 hasConcept C150903083 @default.
• W3158676299 hasConcept C170493617 @default.
• W3158676299 hasConcept C185592680 @default.
• W3158676299 hasConcept C19317047 @default.
• W3158676299 hasConcept C202751555 @default.
• W3158676299 hasConcept C203014093 @default.
• W3158676299 hasConcept C207001950 @default.
• W3158676299 hasConcept C2776090121 @default.
• W3158676299 hasConcept C2780171871 @default.
• W3158676299 hasConcept C55493867 @default.
• W3158676299 hasConcept C70721500 @default.
• W3158676299 hasConcept C86803240 @default.
• W3158676299 hasConcept C8891405 @default.
• W3158676299 hasConcept C95444343 @default.
• W3158676299 hasConceptScore W3158676299C1491633281 @default.
• W3158676299 hasConceptScore W3158676299C150903083 @default.
• W3158676299 hasConceptScore W3158676299C170493617 @default.
• W3158676299 hasConceptScore W3158676299C185592680 @default.
• W3158676299 hasConceptScore W3158676299C19317047 @default.
• W3158676299 hasConceptScore W3158676299C202751555 @default.

• next