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- W3158711697 abstract "Abstract This review summarizes the newly discovered molecular mechanism of secretin‐stimulated urine HCO 3 – excretion and the role of cystic fibrosis transmembrane conductance regulator (CFTR) in renal HCO 3 – excretion. The secretin receptor is functionally expressed in the basolateral membrane of the HCO 3 – ‐secreting β‐intercalated cells of the collecting duct. Here it activates a fast and efficient secretion of HCO 3 – into the urine serving to normalize metabolic alkalosis. The ability to acutely increase renal base excretion is entirely dependent on functional pendrin (SLC26A4) and CFTR, and both proteins localize to the apical membrane of the β‐intercalated cells. In cystic fibrosis mice and patients, this function is absent or markedly reduced. We discuss that the alkaline tide, namely the transient urine alkalinity after a meal, has now received a clear physiological explanation. image" @default.
- W3158711697 created "2021-05-10" @default.
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- W3158711697 date "2021-05-29" @default.
- W3158711697 modified "2023-10-01" @default.
- W3158711697 title "The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion" @default.
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- W3158711697 doi "https://doi.org/10.1113/jp281285" @default.
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