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- W3158711946 abstract "Abstract Vasodilation is a cornerstone of inflammation physiology. By regulating vasodilation and tissue entry of T cells, CD4 + T lymphocytes expressing choline acetyltransferase (ChAT), a key enzyme for biosynthesis of the vasorelaxant acetylcholine (ACh), critically link immunity with vascular biology in mice. However, the characterization of primary human ChAT + T cells remained elusive. Here, we identified human ChAT + T cells and report that ChAT mRNA was induced by activation. Functional studies demonstrated that T cell-derived ACh increased muscarinic ACh-receptor dependent NO-synthase activity and vasorelaxation. Further, single-cell RNA-sequencing revealed ChAT + CD4 + T cells in blood from patients with severe circulatory failure and a high relative frequency of ChAT + CD4 + T cells correlated with better 30-day survival in this cohort. Our findings provide the first insights into ChAT biology in primary human T cells, linking ChAT + T cells with vasorelaxation as well as survival in a cohort of critically ill patients." @default.
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- W3158711946 date "2021-04-28" @default.
- W3158711946 modified "2023-10-01" @default.
- W3158711946 title "Identification and Characterization of Human Activation-Induced ChAT+CD4+ T Cells" @default.
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- W3158711946 doi "https://doi.org/10.1101/2021.04.27.441632" @default.
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