Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158751569> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3158751569 endingPage "43" @default.
- W3158751569 startingPage "36" @default.
- W3158751569 abstract "In order to study the toxicity of 4-methylnitrosamine-1-(3-pyridyl)-1-butanone (NNK) to mice and its relationship with Prx (peroxiredoxin) gene expression, experimental mice were exposed to NNK via intraperitoneal injection (2.5 and 5.0 mg/kg). After 24 weeks, HE (hematoxylin-eosin) staining and qRT-PCR (quantitative real-time polymerase chain reaction) were used to measure the toxicity of NNK on the lung, liver, kidney and testis of the treated mice and NNK's effect on the expression of Prx family genes. The results showed that: 1) Compared with the control group, the mice in the treatment group were more aggressive and had no significant change in food intake, however their body weight decreased five weeks after the exposure. 2) The mice in the treatment group had hyperplasia in alveolar septum, enlargement in hepatic sinuses and nuclei, hyaline degeneration and fragmentation of glomeruli, and decrease of spermatocytes in testicular seminiferous tubules. 3) Under the NNK stress, Prx genes were induced. The Prx gene expression differed in different tissues, the highest expression in the liver tissue was 34.8 times higher than that of the control mice. 4) In the control group, the Prx5 gene expression was lower, while it increased after the NNK treatment, especially at 5.0 mg/kg NNK treatment. Therefore, it is suggested that Prx5 gene might play an important role in anti-oxidation action under NNK stress." @default.
- W3158751569 created "2021-05-10" @default.
- W3158751569 creator A5003921088 @default.
- W3158751569 creator A5005424415 @default.
- W3158751569 creator A5019601191 @default.
- W3158751569 creator A5074028058 @default.
- W3158751569 date "2020-09-24" @default.
- W3158751569 modified "2023-09-25" @default.
- W3158751569 title "Effects of long-term NNK exposure on toxicity and Prx gene expression in mice" @default.
- W3158751569 hasPublicationYear "2020" @default.
- W3158751569 type Work @default.
- W3158751569 sameAs 3158751569 @default.
- W3158751569 citedByCount "0" @default.
- W3158751569 crossrefType "journal-article" @default.
- W3158751569 hasAuthorship W3158751569A5003921088 @default.
- W3158751569 hasAuthorship W3158751569A5005424415 @default.
- W3158751569 hasAuthorship W3158751569A5019601191 @default.
- W3158751569 hasAuthorship W3158751569A5074028058 @default.
- W3158751569 hasConcept C104317684 @default.
- W3158751569 hasConcept C125473707 @default.
- W3158751569 hasConcept C126322002 @default.
- W3158751569 hasConcept C134018914 @default.
- W3158751569 hasConcept C150194340 @default.
- W3158751569 hasConcept C185592680 @default.
- W3158751569 hasConcept C204232928 @default.
- W3158751569 hasConcept C2776151105 @default.
- W3158751569 hasConcept C2777562237 @default.
- W3158751569 hasConcept C29730261 @default.
- W3158751569 hasConcept C503630168 @default.
- W3158751569 hasConcept C55493867 @default.
- W3158751569 hasConcept C71924100 @default.
- W3158751569 hasConcept C86803240 @default.
- W3158751569 hasConceptScore W3158751569C104317684 @default.
- W3158751569 hasConceptScore W3158751569C125473707 @default.
- W3158751569 hasConceptScore W3158751569C126322002 @default.
- W3158751569 hasConceptScore W3158751569C134018914 @default.
- W3158751569 hasConceptScore W3158751569C150194340 @default.
- W3158751569 hasConceptScore W3158751569C185592680 @default.
- W3158751569 hasConceptScore W3158751569C204232928 @default.
- W3158751569 hasConceptScore W3158751569C2776151105 @default.
- W3158751569 hasConceptScore W3158751569C2777562237 @default.
- W3158751569 hasConceptScore W3158751569C29730261 @default.
- W3158751569 hasConceptScore W3158751569C503630168 @default.
- W3158751569 hasConceptScore W3158751569C55493867 @default.
- W3158751569 hasConceptScore W3158751569C71924100 @default.
- W3158751569 hasConceptScore W3158751569C86803240 @default.
- W3158751569 hasIssue "8" @default.
- W3158751569 hasLocation W31587515691 @default.
- W3158751569 hasOpenAccess W3158751569 @default.
- W3158751569 hasPrimaryLocation W31587515691 @default.
- W3158751569 hasRelatedWork W1548809701 @default.
- W3158751569 hasRelatedWork W1581380493 @default.
- W3158751569 hasRelatedWork W1759290447 @default.
- W3158751569 hasRelatedWork W2089277393 @default.
- W3158751569 hasRelatedWork W2094377247 @default.
- W3158751569 hasRelatedWork W2094865753 @default.
- W3158751569 hasRelatedWork W2104378244 @default.
- W3158751569 hasRelatedWork W2296622229 @default.
- W3158751569 hasRelatedWork W2349729159 @default.
- W3158751569 hasRelatedWork W2386325507 @default.
- W3158751569 hasRelatedWork W2404499910 @default.
- W3158751569 hasRelatedWork W2410964865 @default.
- W3158751569 hasRelatedWork W2413114464 @default.
- W3158751569 hasRelatedWork W2518363341 @default.
- W3158751569 hasRelatedWork W2749773136 @default.
- W3158751569 hasRelatedWork W2997760358 @default.
- W3158751569 hasRelatedWork W3025729528 @default.
- W3158751569 hasRelatedWork W3114316452 @default.
- W3158751569 hasRelatedWork W3199764899 @default.
- W3158751569 hasRelatedWork W3203407906 @default.
- W3158751569 hasVolume "53" @default.
- W3158751569 isParatext "false" @default.
- W3158751569 isRetracted "false" @default.
- W3158751569 magId "3158751569" @default.
- W3158751569 workType "article" @default.