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- W3158755312 abstract "Biosynthesized nanoparticles are gaining attention because of biologically active plant secondary metabolites that help in green synthesis and also due to their unique biological applications. This study reports a facile, eco-friendly, reliable, and cost-effective synthesis of silver nanoparticles using the aqueous leaves extract of Logenaria Siceraria (Mol.) Stanoll (L. Siceraria) and their antibacterial and anticancer activity. Silver nanoparticles were biosynthesized using the aqueous leaves extract of L. Siceraria, which acted as a reducing and capping agent. The biosynthesized L. Siceraria silver nanoparticles (Ls-AgNPs) were characterized using different techniques, such as UV−visible spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDAX). Phytochemical analysis was performed to determine the phytochemicals responsible for the reduction and capping of the biosynthesized Ls-AgNPs. The antioxidant activity of the biosynthesized nanoparticles was determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 3- ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. Their antibacterial activity was checked against Staphylococcus aureus (Gram-positive) and Salmonella typhi (Gram-negative) bacteria. The biosynthesized nanoparticles showed dosage-dependent inhibition activity with a significant zone of inhibition and were more effective toward S. typhi as compared to S. aureus. Their anticancer activity was evaluated using 3- (4, 5-dimethylthazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay on selected cancer cell lines. The IC50 values of Ls-AgNPs on A549, MDA-MB-231, HepG2, and MCF-7 were found to be 105.8, 81.1, 94.2, and 65.6μg/mL, respectively, and this showed that the Ls-AgNPs were more potent toward MCF-7 as compared to other cell lines used in this study. This work revealed that the biosynthesized silver nanoparticles using L. Siceraria leaves extract were associated with good antibacterial activity and anticancer potential against selected cancer cell lines. The biosynthesized L. Siceraria AgNPs can be further exploited as a potential candidate for antioxidant, antibacterial, and anticancer agents" @default.
- W3158755312 created "2021-05-10" @default.
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- W3158755312 date "2020-01-01" @default.
- W3158755312 modified "2023-09-28" @default.
- W3158755312 title "Silver nanoparticles of Logenaria siceraria (mol.) stanoll leaves extract for antibacterial and anticancer activity" @default.
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