Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158776616> ?p ?o ?g. }
- W3158776616 endingPage "85" @default.
- W3158776616 startingPage "37" @default.
- W3158776616 abstract "Juvenile hormone (JH) and ecdysteroids represent equally important nonpeptide signals governing insect reproduction and development. For a considerable time, understanding of JH action lagged behind ecdysteroid research. Arriving with a 20-year delay, the intracellular receptor for JH was finally identified as a ligand-activated bHLH-PAS transcription factor, originally named Methoprene-tolerant (Met), by virtue of the resistance Drosophila mutants exhibited to morphogenetic and lethal actions of JH and its mimic methoprene. Systemic RNAi in suitable insect models revealed the anticipated function of Met in preventing metamorphosis and promoting reproduction, thus providing the missing link to the chief roles of JH in insects. That, along with defining the JH-binding pocket and the JH-response DNA elements of Met, established the JH receptor (JHR) 10 years ago. After reviewing the functional attributes of the JHR, this chapter will focus on advances in the genetics, cell biology, and biochemistry of the JHR achieved during this past decade. Although hormone receptor function of bHLH-PAS transcription factors is unprecedented, the well-studied mammalian aryl hydrocarbon receptor (AhR) belonging to the same protein family affords functional parallels with the JHR. We can now begin to understand the mechanisms of JHR interaction with the chaperone Hsp90/83, nucleocytoplasmic transport and post-translational regulation by phosphorylation, dimerization with bHLH-PAS partner proteins, and activation by agonist ligands binding to the PAS-B domain. A section is dedicated to current efforts exploiting the JHR as a basis of chemical high-throughput screening, aimed at discovery of novel compounds for environmentally friendly control of insect pests and disease vectors." @default.
- W3158776616 created "2021-05-10" @default.
- W3158776616 creator A5028462373 @default.
- W3158776616 creator A5052085028 @default.
- W3158776616 creator A5054462849 @default.
- W3158776616 creator A5059210002 @default.
- W3158776616 date "2021-01-01" @default.
- W3158776616 modified "2023-09-29" @default.
- W3158776616 title "A decade with the juvenile hormone receptor" @default.
- W3158776616 cites W1042661505 @default.
- W3158776616 cites W1148268345 @default.
- W3158776616 cites W1483201630 @default.
- W3158776616 cites W1516780286 @default.
- W3158776616 cites W1539107524 @default.
- W3158776616 cites W1560325857 @default.
- W3158776616 cites W1564785963 @default.
- W3158776616 cites W1675449053 @default.
- W3158776616 cites W173051931 @default.
- W3158776616 cites W1815722210 @default.
- W3158776616 cites W1834972362 @default.
- W3158776616 cites W185149704 @default.
- W3158776616 cites W190882786 @default.
- W3158776616 cites W1935479846 @default.
- W3158776616 cites W1944499597 @default.
- W3158776616 cites W1957761960 @default.
- W3158776616 cites W1965737081 @default.
- W3158776616 cites W1966599409 @default.
- W3158776616 cites W1967885926 @default.
- W3158776616 cites W1969255013 @default.
- W3158776616 cites W1970306476 @default.
- W3158776616 cites W1971296208 @default.
- W3158776616 cites W1971402402 @default.
- W3158776616 cites W1971666357 @default.
- W3158776616 cites W1971727708 @default.
- W3158776616 cites W1971897437 @default.
- W3158776616 cites W1976313177 @default.
- W3158776616 cites W1976851982 @default.
- W3158776616 cites W1976879480 @default.
- W3158776616 cites W1977588299 @default.
- W3158776616 cites W1978578751 @default.
- W3158776616 cites W1979841101 @default.
- W3158776616 cites W1981939829 @default.
- W3158776616 cites W1982770749 @default.
- W3158776616 cites W1982850262 @default.
- W3158776616 cites W1985147550 @default.
- W3158776616 cites W1985265839 @default.
- W3158776616 cites W1986321253 @default.
- W3158776616 cites W1986843144 @default.
- W3158776616 cites W1989353024 @default.
- W3158776616 cites W1992458439 @default.
- W3158776616 cites W1993056741 @default.
- W3158776616 cites W1995728826 @default.
- W3158776616 cites W1997520610 @default.
- W3158776616 cites W1997769816 @default.
- W3158776616 cites W1999609280 @default.
- W3158776616 cites W2000589669 @default.
- W3158776616 cites W2001002869 @default.
- W3158776616 cites W2006334693 @default.
- W3158776616 cites W2008199045 @default.
- W3158776616 cites W2008702561 @default.
- W3158776616 cites W2009028852 @default.
- W3158776616 cites W2012245110 @default.
- W3158776616 cites W2014861681 @default.
- W3158776616 cites W2016529877 @default.
- W3158776616 cites W2016632846 @default.
- W3158776616 cites W2017631678 @default.
- W3158776616 cites W2021212531 @default.
- W3158776616 cites W2022416579 @default.
- W3158776616 cites W2023147329 @default.
- W3158776616 cites W2023387306 @default.
- W3158776616 cites W2026060525 @default.
- W3158776616 cites W2030152947 @default.
- W3158776616 cites W2031618137 @default.
- W3158776616 cites W2033500368 @default.
- W3158776616 cites W2033552012 @default.
- W3158776616 cites W2034526088 @default.
- W3158776616 cites W2035711164 @default.
- W3158776616 cites W2036139759 @default.
- W3158776616 cites W2036505063 @default.
- W3158776616 cites W2037280340 @default.
- W3158776616 cites W2039128629 @default.
- W3158776616 cites W2041118310 @default.
- W3158776616 cites W2042271211 @default.
- W3158776616 cites W2044674065 @default.
- W3158776616 cites W2044920259 @default.
- W3158776616 cites W2045217496 @default.
- W3158776616 cites W2045241135 @default.
- W3158776616 cites W2045762442 @default.
- W3158776616 cites W2047831572 @default.
- W3158776616 cites W2051435997 @default.
- W3158776616 cites W2051660611 @default.
- W3158776616 cites W2052410382 @default.
- W3158776616 cites W2053244650 @default.
- W3158776616 cites W2055659890 @default.
- W3158776616 cites W2057708838 @default.
- W3158776616 cites W2059408083 @default.
- W3158776616 cites W2059633052 @default.
- W3158776616 cites W2061927465 @default.