Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158777889> ?p ?o ?g. }
- W3158777889 endingPage "2018" @default.
- W3158777889 startingPage "2006" @default.
- W3158777889 abstract "Objective: Lymphatic vessels are distributed throughout the body and tightly collaborate with blood vessels to maintain tissue homeostasis. However, the functional roles of lymphangiogenesis in the process of reparative angiogenesis in ischemic tissues are largely unknown. Accordingly, we investigated potential roles of lymphangiogenesis using a mouse model of ischemia-induced angiogenesis. Approach and Results: Male C57BL/6J mice were subjected to unilateral hindlimb ischemia, in which not only angiogenesis but also lymphangiogenesis was induced. Next, the excessive and prolonged tissue edema model significantly deteriorated reparative angiogenesis and blood perfusion recovery in ischemic limbs. Finally, implantation of adipose-derived regenerative cells augmented ischemia-induced lymphangiogenesis, which was accompanied by reduced tissue edema and inflammation, resulting in improving reparative angiogenesis and blood perfusion recovery. In addition, inhibition of lymphangiogenesis by MAZ51, a specific VEGFR3 (vascular endothelial cell growth factor receptor 3) inhibitor, resulted in enhanced inflammatory cell infiltration, gene expression of TNF (tumor necrosis factor)-α, IL (interleukin)-1β, IL-6, TGF (transforming growth factor)-β, angiostatin, vasohibin, and endostatin, and tissue edema, resulting in reduced angiogenesis. Conclusions: The lymphatic system may have a clearance role of tissue edema and inflammation, which contribute to functional reparative angiogenesis in response to tissue ischemia. Modulation of lymphangiogenesis would become a novel therapeutic strategy for severe ischemic disease in addition to ordinary vascular intervention and therapeutic angiogenesis." @default.
- W3158777889 created "2021-05-10" @default.
- W3158777889 creator A5002307162 @default.
- W3158777889 creator A5017902899 @default.
- W3158777889 creator A5020050750 @default.
- W3158777889 creator A5021155060 @default.
- W3158777889 creator A5034179596 @default.
- W3158777889 creator A5041987541 @default.
- W3158777889 creator A5051547398 @default.
- W3158777889 creator A5059306205 @default.
- W3158777889 creator A5059311784 @default.
- W3158777889 creator A5059574997 @default.
- W3158777889 creator A5074806417 @default.
- W3158777889 creator A5077535251 @default.
- W3158777889 creator A5079396922 @default.
- W3158777889 creator A5086905123 @default.
- W3158777889 creator A5090747574 @default.
- W3158777889 date "2021-06-01" @default.
- W3158777889 modified "2023-10-14" @default.
- W3158777889 title "Important Role of Concomitant Lymphangiogenesis for Reparative Angiogenesis in Hindlimb Ischemia" @default.
- W3158777889 cites W1489873347 @default.
- W3158777889 cites W186245066 @default.
- W3158777889 cites W1978848582 @default.
- W3158777889 cites W1983556635 @default.
- W3158777889 cites W1987399881 @default.
- W3158777889 cites W2001375090 @default.
- W3158777889 cites W2006122359 @default.
- W3158777889 cites W2021787814 @default.
- W3158777889 cites W2022366199 @default.
- W3158777889 cites W2041404029 @default.
- W3158777889 cites W2043302297 @default.
- W3158777889 cites W2043410848 @default.
- W3158777889 cites W2044689705 @default.
- W3158777889 cites W2059322719 @default.
- W3158777889 cites W2071361108 @default.
- W3158777889 cites W2072927676 @default.
- W3158777889 cites W2072928113 @default.
- W3158777889 cites W2076229475 @default.
- W3158777889 cites W2077744767 @default.
- W3158777889 cites W2088393488 @default.
- W3158777889 cites W2095002343 @default.
- W3158777889 cites W2095857179 @default.
- W3158777889 cites W2097384952 @default.
- W3158777889 cites W2112267683 @default.
- W3158777889 cites W2120033284 @default.
- W3158777889 cites W2129081579 @default.
- W3158777889 cites W2129170976 @default.
- W3158777889 cites W2131798870 @default.
- W3158777889 cites W2132992599 @default.
- W3158777889 cites W2137061409 @default.
- W3158777889 cites W2138274682 @default.
- W3158777889 cites W2146670463 @default.
- W3158777889 cites W2166849471 @default.
- W3158777889 cites W2252733902 @default.
- W3158777889 cites W2307162179 @default.
- W3158777889 cites W2309280628 @default.
- W3158777889 cites W2328655798 @default.
- W3158777889 cites W2742705071 @default.
- W3158777889 cites W2781838311 @default.
- W3158777889 cites W2791082149 @default.
- W3158777889 cites W2791362877 @default.
- W3158777889 cites W2802715841 @default.
- W3158777889 cites W2893840462 @default.
- W3158777889 cites W2894231557 @default.
- W3158777889 cites W2916685189 @default.
- W3158777889 cites W2950612186 @default.
- W3158777889 cites W3091368378 @default.
- W3158777889 cites W4249769808 @default.
- W3158777889 doi "https://doi.org/10.1161/atvbaha.121.316191" @default.
- W3158777889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33910373" @default.
- W3158777889 hasPublicationYear "2021" @default.
- W3158777889 type Work @default.
- W3158777889 sameAs 3158777889 @default.
- W3158777889 citedByCount "8" @default.
- W3158777889 countsByYear W31587778892022 @default.
- W3158777889 countsByYear W31587778892023 @default.
- W3158777889 crossrefType "journal-article" @default.
- W3158777889 hasAuthorship W3158777889A5002307162 @default.
- W3158777889 hasAuthorship W3158777889A5017902899 @default.
- W3158777889 hasAuthorship W3158777889A5020050750 @default.
- W3158777889 hasAuthorship W3158777889A5021155060 @default.
- W3158777889 hasAuthorship W3158777889A5034179596 @default.
- W3158777889 hasAuthorship W3158777889A5041987541 @default.
- W3158777889 hasAuthorship W3158777889A5051547398 @default.
- W3158777889 hasAuthorship W3158777889A5059306205 @default.
- W3158777889 hasAuthorship W3158777889A5059311784 @default.
- W3158777889 hasAuthorship W3158777889A5059574997 @default.
- W3158777889 hasAuthorship W3158777889A5074806417 @default.
- W3158777889 hasAuthorship W3158777889A5077535251 @default.
- W3158777889 hasAuthorship W3158777889A5079396922 @default.
- W3158777889 hasAuthorship W3158777889A5086905123 @default.
- W3158777889 hasAuthorship W3158777889A5090747574 @default.
- W3158777889 hasBestOaLocation W31587778891 @default.
- W3158777889 hasConcept C121608353 @default.
- W3158777889 hasConcept C126322002 @default.
- W3158777889 hasConcept C142724271 @default.
- W3158777889 hasConcept C167734588 @default.
- W3158777889 hasConcept C181152851 @default.