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• W3158778652 abstract "Abstract Natural Killer (NK) cells are among the first effectors to directly contact influenza and influenza-infected cells and their activation affects not only their intrinsic functions, but also subsequent CD8 + T cell responses. We utilized a NK cell depletion model to interrogate the contribution of NK cells to the development of anti-influenza CD8 + T cell memory. NK cell ablation increased the number of influenza-specific memory CD8 + T cells in the respiratory tract and lung-draining lymph node. Interestingly, animals depleted of NK cells during primary influenza infection were protected as well as their NK-intact counterparts despite significantly fewer reactivated CD8 + T cells infiltrating the respiratory tract after lethal, heterosubtypic challenge. Instead, protection in NK-deficient animals seems to be conferred by rapid reactivation of an enlarged pool of lung tissue-resident (T RM ) memory cells within two days post challenge. Further interrogation of how NK cell ablation enhances respiratory T RM indicated that T RM development is independent of global and NK cell derived IFN-γ. These data suggest that reduction in NK cell activation after vaccination with live, non-lethal influenza virus increases compartmentalized, broadly protective memory CD8 + T cell generation and decreases the risk of CD8 + T cell-mediated pathology following subsequent influenza infections." @default.
• W3158778652 created "2021-05-10" @default.
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• W3158778652 date "2021-04-26" @default.
• W3158778652 modified "2023-10-16" @default.
• W3158778652 title "Enhanced generation of influenza-specific tissue resident memory CD8 T cells in NK-depleted mice" @default.
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• W3158778652 doi "https://doi.org/10.1038/s41598-021-88268-7" @default.
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