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• W3158788475 abstract "Spinal cord stimulation (SCS) for pain is usually implanted as an open loop system using unchanged parameters. To avoid the under and over stimulation caused by lead migration, evoked compound action potentials (ECAP) is used as feedback signal to change the stimulating parameters. This study established a simulation model of ECAP recording to investigate the relationship between ECAP component and dorsal column (DC) fiber recruitment. Finite element model of SCS and multi-compartment model of sensory fiber were coupled to calculate the single fiber action potential (SFAP) caused by single fiber in different spinal cord regions. The synthetized ECAP, superimposition of SFAP, could be considered as an index of DC fiber excitation degree, because the position of crests and amplitude of ECAP corresponds to different fiber diameters. When 10% or less DC fibers were excited, the crests corresponded to fibers with large diameters. When 20% or more DC fibers were excited, ECAP showed a slow conduction crest, which corresponded to fibers with small diameters. The amplitude of this slow conduction crest increased as the stimulating intensity increased while the amplitude of the fast conduction crest almost remained unchanged. Therefore, the simulated ECAP signal in this paper could be used to evaluate the degree of excitation of DC fibers. This SCS-ECAP model may provide theoretical basis for future clinical application of close loop SCS base on ECAP.脊髓电刺激（SCS）治疗慢性疼痛以一种开环的方式植入，植入后刺激参数一般保持不变。为了避免电极位置变化引起刺激强度不足或过度刺激，可以利用 SCS 电极记录的诱发复合动作电位（ECAP）作为反馈信号，来调整刺激参数。本文建立了 SCS 同步记录 ECAP 的仿真模型，并研究 ECAP 波形与脊髓背侧柱（DC）纤维兴奋程度之间的关系。通过 SCS 有限元仿真模型和感觉纤维多房室电缆模型的耦合计算 SCS 作用下由膜电流引起的单纤维动作电位（SFAP），将 SFAP 叠加获得电极上记录的差分形式的 ECAP 信号。仿真结果表明 ECAP 中不同的波谷对应着不同直径的感觉纤维，由波谷位置和幅值可以判断 DC 纤维兴奋程度。不超过 10% DC 纤维兴奋时的 ECAP 波谷对应着大直径感觉纤维，20% 及以上 DC 纤维兴奋时出现慢传导的波谷，对应着小直径感觉纤维，且 DC 纤维兴奋程度越高，波谷幅值越大，但大直径纤维对应的波谷幅值保持不变。本文建立的 SCS 同步采集 ECAP 仿真模型可以模拟 ECAP 信号并由波谷位置和幅度判断 DC 纤维兴奋程度，进而判定刺激强度过小、适当或过大，为基于 ECAP 的闭环 SCS 在未来的临床应用提供理论依据。." @default.
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• W3158788475 date "2021-04-25" @default.
• W3158788475 modified "2023-09-23" @default.
• W3158788475 title "[Simulation study of spinal cord stimulation evoked compound action potential]." @default.
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• W3158788475 doi "https://doi.org/10.7507/1001-5515.202007016" @default.
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