Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158800743> ?p ?o ?g. }
- W3158800743 endingPage "100834" @default.
- W3158800743 startingPage "100834" @default.
- W3158800743 abstract "Thromboembolic events represent the most common complication of hemolytic anemias characterized by complement-mediated hemolysis such as paroxysmal nocturnal hemoglobinuria and autoimmune hemolytic anemia. Similarly, atypical hemolytic uremic syndrome is characterized by hemolysis and thrombotic abnormalities. The main player in the development of thrombosis in hemolytic diseases is suggested to be the complement system. However, the release of extracellular hemoglobin and heme by hemolysis itself can also drive procoagulant responses. Both, complement activation and hemolysis promote the activation of neutrophils resulting in the formation of neutrophil extracellular traps and induce inflammation and vascular damage which all together might (synergistically) lead to hypercoagulability. In this review we aim to summarize the current knowledge on the role of complement activation and hemolysis in the onset of thrombosis in hemolytic diseases. This review will discuss the interplay between different biological systems and neutrophil activation contributing to the pathogenesis of thrombosis. Finally, we will combine this fundamental knowledge and address the pathophysiology of hemolysis in prototypical complement-driven diseases." @default.
- W3158800743 created "2021-05-10" @default.
- W3158800743 creator A5079300413 @default.
- W3158800743 creator A5080818853 @default.
- W3158800743 creator A5085380635 @default.
- W3158800743 date "2021-11-01" @default.
- W3158800743 modified "2023-10-17" @default.
- W3158800743 title "It takes two to thrombosis: Hemolysis and complement" @default.
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