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• W3158808944 abstract "• ABO-incompatible kidney transplant requires extensive preconditioning for desensitization and immunosuppression. • Early graft function is affected by ischemic-reperfusion injury involving immune systems. • We retrospectively examined a single-institution database to assess the factors associated with early graft function. • Prolonged cold ischemic time and ABO incompatibility affected early graft function in living donor kidney transplantation. We investigated the association between ABO-incompatible (ABO-I) kidney transplantation and early graft function. We retrospectively analyzed 95 patients who underwent living donor kidney transplantation between May 2009 and July 2019. It included 61 ABO-compatible (ABO-C) and 34 ABO-I transplantations. We extracted data on immunologic profile, sex, age, cold ischemic time, type of immunosuppression, and graft function. Two definitions were used for slow graft function (SGF) as follows: postoperative day (POD) 3 serum creatinine level >3 mg/dL and estimated glomerular filtration rate (eGFR) <20 mL/min/1.73 m 2 . Logistic regression analysis was performed to analyze the effect of ABO-I on the incidence of SGF. The characteristics between the ABO-C and ABO-I were not different. ABO-I received rituximab and plasma exchange. Patients also received tacrolimus and mycophenolate mofetil for 2 weeks and prednisolone for 1 week before transplantation as preconditioning. Of the 95 study patients, 19 (20%) and 21 (22%) were identified with SGF according to POD 3 serum creatinine level or eGFR, respectively. Multivariable analysis revealed that ABO-I significantly reduced the incidence of SGF (odds ratio, 0.15; 95% confidence interval, 0.03-0.7; P = .02), and cold ischemic time >150 min increased the incidence of SGF (odds ratio, 6.5; 95% confidence interval, 1.7-25; P = .006). Similar results were identified in POD 3 eGFR. Inferior graft function in patients with SGF was identified up to 6 months after transplantation. ABO-I reduces the incidence of SGF, which is associated with an inferior graft function up to 6 months." @default.
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• W3158808944 date "2021-06-01" @default.
• W3158808944 modified "2023-10-01" @default.
• W3158808944 title "ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study" @default.
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• W3158808944 doi "https://doi.org/10.1016/j.transproceed.2021.03.043" @default.
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