Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158816625> ?p ?o ?g. }
- W3158816625 abstract "Filarial nematodes secrete bioactive molecules which are of interest as potential mediators for manipulating host biology, as they are readily available at the host-parasite interface. The adult parasites can survive for years in the mammalian host, due to their successful modulation of the host immune system and most of these immunomodulatory strategies are based on soluble mediators excreted by the parasite. The secretome of filarial nematodes is a key player in both infection and pathology, making them an interesting target for further investigation. This review summarises the current knowledge regarding the components of the excretory-secretory products (ESPs) of filarial parasites and their bioactive functions in the human host. In addition, the pathogenic potential of the identified components, which are mostly proteins, in the pathophysiology of onchocerciasis-associated epilepsy is discussed." @default.
- W3158816625 created "2021-05-10" @default.
- W3158816625 creator A5020612855 @default.
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- W3158816625 date "2021-04-28" @default.
- W3158816625 modified "2023-09-25" @default.
- W3158816625 title "The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy" @default.
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- W3158816625 doi "https://doi.org/10.3389/fcimb.2021.662766" @default.
- W3158816625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8113626" @default.
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- W3158816625 hasPublicationYear "2021" @default.
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