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• W3158823688 abstract "ABSTRACT Background Mucosal associated invariant T (MAIT) cells are semi-invariant T cells that recognize microbial antigens presented by the highly conserved MR1 molecule. MAIT cells are predominantly localized in the liver and barrier tissues and are potent effectors of anti - microbial defense. MAIT cells are very few at birth and accumulate gradually over a period of about 6 years during infancy. The cytotoxic potential of MAIT cells, as well as their newly described regulatory and tissue repair functions, open the possibility of exploiting their properties in adoptive therapy. A prerequisite for their use as “universal” cells would be a lack of alloreactive potential, which remains to be demonstrated. Methods We used ex vivo, in vitro and in vivo models to determine if human MAIT cells contribute to allogeneic responses. Results We show that recovery of MAIT cells after allogeneic hematopoietic stem cell transplantation recapitulates their slow physiological expansion in early childhood, independent of recovery of conventional T cells. In vitro , signals provided by allogeneic cells and cytokines do not induce sustained MAIT cell proliferation. In vivo , human MAIT cells do not expand nor accumulate in tissues in a model of T-cell mediated xenogeneic graft-versus-host disease (GVHD) in immunodeficient mice. Conclusions Altogether, these results provide evidence that MAIT cells are devoid of alloreactive potential and pave the way for harnessing their translational potential in universal adoptive therapy overcoming barriers of HLA disparity." @default.
• W3158823688 created "2021-05-10" @default.
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• W3158823688 date "2021-04-30" @default.
• W3158823688 modified "2023-10-17" @default.
• W3158823688 title "Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy" @default.
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• W3158823688 doi "https://doi.org/10.1101/2021.04.29.21256184" @default.
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