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- W3158832557 abstract "Herein, a drug nanocarrier capable of recognizing sialic acid (SA) was prepared by grafting SA-imprinted hydrogel layer on mesoporous silica nanoparticles (MSNs). On cancer cells, the terminal of glycoproteins and lipids on cell membrane usually overexpression of SA, thus SA-imprinted mesoporous nanocarriers (SIMNs) may show cancer selectivity and targeted drug delivery. In this study, a typical therapeutic drug doxorubicin (DOX) was filled into the mesoporous channels of SIMNs to obtain a DOX-loaded nanomaterial (SIMNs@DOX). Human hepatocellular carcinoma cells (HepG-2) were selected to demonstrated the tumor targeted drug delivery of SIMNs@DOX. We verified that the combination of mesoporous nanocarriers with SA recognition sites gives our SIMNs@DOX the ability to target SA-overexpressed cancer cells and enhance cancer cellular uptake, finally leading to improved inhibition of cancer cell proliferation. Our study would offer a good idea for the engineering of drug nanocarriers with targeted cancer theranostics. • A sialic acid (SA)-imprinted mesoporous silica nanocarrier was prepared and characterized. • The SA-imprinted mesoporous nanocarrier could target cancer cells and improve cellular uptake. • The SA-imprinted mesoporous nanocarrier could achieve targeted drug delivery and enhance cancer cell inhibition." @default.
- W3158832557 created "2021-05-10" @default.
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- W3158832557 date "2021-05-01" @default.
- W3158832557 modified "2023-10-15" @default.
- W3158832557 title "Sialic acid-imprinted mesoporous nanocarriers for tumor cell targeted drug delivery" @default.
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- W3158832557 doi "https://doi.org/10.1016/j.colcom.2021.100421" @default.
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