FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3158847089> ?p ?o ?g. }

• W3158847089 endingPage "1328" @default.
• W3158847089 startingPage "1318" @default.
• W3158847089 abstract "Abstract Objective Sudden unexpected death in epilepsy (SUDEP) may arise as a result of autonomic dysfunction during a seizure. The central autonomic networks (CANs) modulate brainstem cardiorespiratory regulation. Recent magnetic resonance imaging (MRI) studies in SUDEP have shown cortical and subcortical volume changes and altered connectivity between CAN regions, but the pathological correlate is unknown. Because neuroinflammation is both a cause and a consequence of seizures and may relate to regional brain pathology, our aim was to evaluate microglial populations in CANs in SUDEP. Methods In 55 postmortem cases, including SUDEP, epilepsy controls without SUDEP and nonepilepsy controls, we quantified Iba1‐expressing microglia in 14 cortical and thalamic areas that included known CAN regions. Results Mean Iba1 labeling across all brain regions was significantly higher in SUDEP cases compared to epilepsy and nonepilepsy controls. There was significant regional variation in Iba1 labeling in SUDEP cases only, with highest labeling in the medial thalamus. Significantly higher labeling in SUDEP cases than epilepsy and nonepilepsy controls was consistently noted in the superior temporal gyrus. In cases with documented seizures up to 10 days prior to death, significantly higher mean Iba1 labeling was observed in SUDEP compared to epilepsy controls. Significance Our findings support microglial activation in SUDEP, including cortical and subcortical regions with known autonomic functions such as the thalamus and superior temporal gyrus. This may be relevant to cellular pathomechanisms underlying cardioregulatory failure during a seizure." @default.
• W3158847089 created "2021-05-10" @default.
• W3158847089 creator A5014499788 @default.
• W3158847089 creator A5049258088 @default.
• W3158847089 creator A5060537820 @default.
• W3158847089 creator A5067939542 @default.
• W3158847089 creator A5074816207 @default.
• W3158847089 date "2021-05-04" @default.
• W3158847089 modified "2023-10-15" @default.
• W3158847089 title "Regional microglial populations in central autonomic brain regions in SUDEP" @default.
• W3158847089 cites W1549808427 @default.
• W3158847089 cites W1576277997 @default.
• W3158847089 cites W1933496370 @default.
• W3158847089 cites W1985623917 @default.
• W3158847089 cites W2022981588 @default.
• W3158847089 cites W2025617956 @default.
• W3158847089 cites W2028885320 @default.
• W3158847089 cites W2053176712 @default.
• W3158847089 cites W2055575271 @default.
• W3158847089 cites W2068592783 @default.
• W3158847089 cites W2100391275 @default.
• W3158847089 cites W2127126677 @default.
• W3158847089 cites W2135733572 @default.
• W3158847089 cites W2146894060 @default.
• W3158847089 cites W2231858474 @default.
• W3158847089 cites W2327380846 @default.
• W3158847089 cites W2564772759 @default.
• W3158847089 cites W2579611109 @default.
• W3158847089 cites W2579705165 @default.
• W3158847089 cites W2605483677 @default.
• W3158847089 cites W2759409764 @default.
• W3158847089 cites W2792405568 @default.
• W3158847089 cites W2793978211 @default.
• W3158847089 cites W2795098017 @default.
• W3158847089 cites W2884139971 @default.
• W3158847089 cites W2886384416 @default.
• W3158847089 cites W2916001803 @default.
• W3158847089 cites W2920386143 @default.
• W3158847089 cites W2921261195 @default.
• W3158847089 cites W2943474034 @default.
• W3158847089 cites W2949280410 @default.
• W3158847089 cites W2955578722 @default.
• W3158847089 cites W2962888202 @default.
• W3158847089 cites W2978895138 @default.
• W3158847089 cites W2982552014 @default.
• W3158847089 cites W3001992249 @default.
• W3158847089 cites W3012088083 @default.
• W3158847089 cites W3014258685 @default.
• W3158847089 cites W3020746890 @default.
• W3158847089 cites W3036099501 @default.
• W3158847089 cites W3043084974 @default.
• W3158847089 cites W3049470876 @default.
• W3158847089 cites W3081345152 @default.
• W3158847089 cites W3088494006 @default.
• W3158847089 cites W3093872762 @default.
• W3158847089 doi "https://doi.org/10.1111/epi.16904" @default.
• W3158847089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33942290" @default.
• W3158847089 hasPublicationYear "2021" @default.
• W3158847089 type Work @default.
• W3158847089 sameAs 3158847089 @default.
• W3158847089 citedByCount "13" @default.
• W3158847089 countsByYear W31588470892021 @default.
• W3158847089 countsByYear W31588470892022 @default.
• W3158847089 countsByYear W31588470892023 @default.
• W3158847089 crossrefType "journal-article" @default.
• W3158847089 hasAuthorship W3158847089A5014499788 @default.
• W3158847089 hasAuthorship W3158847089A5049258088 @default.
• W3158847089 hasAuthorship W3158847089A5060537820 @default.
• W3158847089 hasAuthorship W3158847089A5067939542 @default.
• W3158847089 hasAuthorship W3158847089A5074816207 @default.
• W3158847089 hasBestOaLocation W31588470892 @default.
• W3158847089 hasConcept C142724271 @default.
• W3158847089 hasConcept C15744967 @default.
• W3158847089 hasConcept C169760540 @default.
• W3158847089 hasConcept C207886595 @default.
• W3158847089 hasConcept C2775956885 @default.
• W3158847089 hasConcept C2778186239 @default.
• W3158847089 hasConcept C2779134260 @default.
• W3158847089 hasConcept C2779226451 @default.
• W3158847089 hasConcept C2779246727 @default.
• W3158847089 hasConcept C2779369059 @default.
• W3158847089 hasConcept C2781099131 @default.
• W3158847089 hasConcept C551621295 @default.
• W3158847089 hasConcept C71924100 @default.
• W3158847089 hasConcept C87753298 @default.
• W3158847089 hasConceptScore W3158847089C142724271 @default.
• W3158847089 hasConceptScore W3158847089C15744967 @default.
• W3158847089 hasConceptScore W3158847089C169760540 @default.
• W3158847089 hasConceptScore W3158847089C207886595 @default.
• W3158847089 hasConceptScore W3158847089C2775956885 @default.
• W3158847089 hasConceptScore W3158847089C2778186239 @default.
• W3158847089 hasConceptScore W3158847089C2779134260 @default.
• W3158847089 hasConceptScore W3158847089C2779226451 @default.
• W3158847089 hasConceptScore W3158847089C2779246727 @default.
• W3158847089 hasConceptScore W3158847089C2779369059 @default.
• W3158847089 hasConceptScore W3158847089C2781099131 @default.
• W3158847089 hasConceptScore W3158847089C551621295 @default.
• W3158847089 hasConceptScore W3158847089C71924100 @default.

• next