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- W3158889697 abstract "Sirtuins have been shown to regulate the aging process. We have previously demonstrated that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show that Sirt6 can also mitigate aging-induced cardiomyocyte senescence and cardiac hypertrophy. We found that aging is associated with altered Sirt6 activity along with development of cardiac hypertrophy and fibrosis. Compared to young mice (4-months), the hearts of aged mice (24-months) showed increased levels of mitochondrial DNA damage, shortened telomere length, and increased accumulation of 8-oxo-dG adducts, which are hallmarks of aging. The aged hearts also showed reduced levels of NAD+ and altered levels of mitochondrial fusion-fission proteins. Similar characteristics were observed in the hearts of Sirt6 deficient mice. Additionally, we found that doxorubicin (Dox) induced cardiomyocyte senescence, as measured by expression of p16INK4a, p53, and β-galactosidase, was associated with loss of Sirt6. However, Sirt6 overexpression protected cardiomyocytes from developing Dox-induced senescence. Further, compared to wild-type mice, the hearts of Sirt6.Tg mice showed reduced expression of aging markers, and the development of aging-associated cardiac hypertrophy and fibrosis. Our data suggest that Sirt6 is a critical anti-aging molecule that regulates various cellular processes associated with aging and protects the heart from developing aging-induced cardiac hypertrophy and fibrosis." @default.
- W3158889697 created "2021-05-10" @default.
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- W3158889697 date "2021-05-02" @default.
- W3158889697 modified "2023-09-30" @default.
- W3158889697 title "The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy" @default.
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- W3158889697 cites W2018559644 @default.
- W3158889697 cites W2023500065 @default.
- W3158889697 cites W2026761826 @default.
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- W3158889697 cites W2034137026 @default.
- W3158889697 cites W2034564804 @default.
- W3158889697 cites W2037603814 @default.
- W3158889697 cites W2041061895 @default.
- W3158889697 cites W2042716686 @default.
- W3158889697 cites W2044929466 @default.
- W3158889697 cites W2045390356 @default.
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- W3158889697 doi "https://doi.org/10.18632/aging.203027" @default.
- W3158889697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8148452" @default.
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- W3158889697 hasPublicationYear "2021" @default.
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