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• W3158921021 abstract "Abstract Background The skeletal muscle reconstruction occurs thanks to unipotent stem cells, i.e., satellite cells. The satellite cells remain quiescent and localized between myofiber sarcolemma and basal lamina. They are activated in response to muscle injury, proliferate, differentiate into myoblasts, and recreate myofibers. The stem and progenitor cells support skeletal muscle regeneration, which could be disturbed by extensive damage, sarcopenia, cachexia, or genetic diseases like dystrophy. Many lines of evidence showed that the level of oxygen regulates the course of cell proliferation and differentiation. Methods In the present study, we analyzed hypoxia impact on human and pig bone marrow-derived mesenchymal stromal cell (MSC) and mouse myoblast proliferation, differentiation, and fusion. Moreover, the influence of the transplantation of human bone marrow-derived MSCs cultured under hypoxic conditions on skeletal muscle regeneration was studied. Results We showed that bone marrow-derived MSCs increased VEGF expression and improved myogenesis under hypoxic conditions in vitro. Transplantation of hypoxia preconditioned bone marrow-derived MSCs into injured muscles resulted in the improved cell engraftment and formation of new vessels. Conclusions We suggested that SDF-1 and VEGF secreted by hypoxia preconditioned bone marrow-derived MSCs played an essential role in cell engraftment and angiogenesis. Importantly, hypoxia preconditioned bone marrow-derived MSCs more efficiently engrafted injured muscles; however, they did not undergo myogenic differentiation." @default.
• W3158921021 created "2021-05-10" @default.
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• W3158921021 date "2021-08-09" @default.
• W3158921021 modified "2023-10-01" @default.
• W3158921021 title "Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration" @default.
• W3158921021 cites W1255984457 @default.
• W3158921021 cites W1515952044 @default.
• W3158921021 cites W1819309358 @default.
• W3158921021 cites W1880888943 @default.
• W3158921021 cites W1894976709 @default.
• W3158921021 cites W1964849541 @default.
• W3158921021 cites W1970590932 @default.
• W3158921021 cites W1973723008 @default.
• W3158921021 cites W1979755851 @default.
• W3158921021 cites W1981141119 @default.
• W3158921021 cites W1981180583 @default.
• W3158921021 cites W1982274138 @default.
• W3158921021 cites W1985688738 @default.
• W3158921021 cites W1987030748 @default.
• W3158921021 cites W1993925802 @default.
• W3158921021 cites W1994702815 @default.
• W3158921021 cites W1994805418 @default.
• W3158921021 cites W1995906570 @default.
• W3158921021 cites W1998650056 @default.
• W3158921021 cites W2005536668 @default.
• W3158921021 cites W2007043944 @default.
• W3158921021 cites W2011014862 @default.
• W3158921021 cites W2013621644 @default.
• W3158921021 cites W2017429680 @default.
• W3158921021 cites W2019921405 @default.
• W3158921021 cites W2021826201 @default.
• W3158921021 cites W2022937488 @default.
• W3158921021 cites W2025547446 @default.
• W3158921021 cites W2027322108 @default.
• W3158921021 cites W2032171199 @default.
• W3158921021 cites W2035772798 @default.
• W3158921021 cites W2042736567 @default.
• W3158921021 cites W2043123806 @default.
• W3158921021 cites W2052651806 @default.
• W3158921021 cites W2057242413 @default.
• W3158921021 cites W2060092038 @default.
• W3158921021 cites W2062221785 @default.
• W3158921021 cites W2063601357 @default.
• W3158921021 cites W2066272256 @default.
• W3158921021 cites W2066954473 @default.
• W3158921021 cites W2067115133 @default.
• W3158921021 cites W2069565002 @default.
• W3158921021 cites W2070773381 @default.
• W3158921021 cites W2072386632 @default.
• W3158921021 cites W2077709457 @default.
• W3158921021 cites W2079812792 @default.
• W3158921021 cites W2085707330 @default.
• W3158921021 cites W2087803244 @default.
• W3158921021 cites W2088755431 @default.
• W3158921021 cites W2095618136 @default.
• W3158921021 cites W2097932206 @default.
• W3158921021 cites W2100744265 @default.
• W3158921021 cites W2104413464 @default.
• W3158921021 cites W2104551938 @default.
• W3158921021 cites W2107016814 @default.
• W3158921021 cites W2107985768 @default.
• W3158921021 cites W2108723188 @default.
• W3158921021 cites W2111704421 @default.
• W3158921021 cites W2112039060 @default.
• W3158921021 cites W2117904914 @default.
• W3158921021 cites W2118533478 @default.
• W3158921021 cites W2119406072 @default.
• W3158921021 cites W2119767687 @default.
• W3158921021 cites W2121964349 @default.
• W3158921021 cites W2123429544 @default.
• W3158921021 cites W2124699186 @default.
• W3158921021 cites W2127466012 @default.
• W3158921021 cites W2127687868 @default.
• W3158921021 cites W2129853613 @default.
• W3158921021 cites W2131092033 @default.
• W3158921021 cites W2134614924 @default.
• W3158921021 cites W2137508766 @default.
• W3158921021 cites W2138313400 @default.
• W3158921021 cites W2144067550 @default.
• W3158921021 cites W2149674290 @default.
• W3158921021 cites W2150395635 @default.
• W3158921021 cites W2155243243 @default.
• W3158921021 cites W2157059052 @default.
• W3158921021 cites W2159442019 @default.
• W3158921021 cites W2163573140 @default.

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