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• W3158954198 abstract "Abstract Purpose Meningiomas are the most common primary intracranial neoplasms. Their volume and location are important factors related to the appearance of clinical symptoms. This study aimed to identify factors that influence clinical symptoms and to determine a specific threshold tumor volume for the prediction of symptomatic progression in patients with convexity, parasagittal, and falx meningiomas. Methods We retrospectively studied patients with radiologically suspected convexity, parasagittal, or falx meningiomas at our institution. Results The data of three hundred thirty-three patients were analyzed. We further divided patients into two groups based on clinical symptoms: as asymptomatic group (250 cases) and a symptomatic group (83 cases). Univariate analysis revealed significant differences between the groups in terms of sex ( p = 0.002), age at the time of volumetric analysis ( p < 0.001), hyperintense lesions on T2-weighted images ( p = 0.029), peritumoral edema ( p < 0.001), maximum tumor diameter ( p < 0.001), and tumor volume ( p < 0.001). Further multivariate analysis revealed significant differences between the groups in terms of age at the time of volumetric analysis ( p = 0.002), peritumoral edema ( p < 0.001), and tumor volume ( p < 0.001). Receiver operating characteristic curve revealed a threshold tumor volume of 21.1 ml for predicting whether a patient would develop symptoms (sensitivity 0.843, specificity 0.880, an area under the curve 0.919 [95% confidence interval: 0.887–0.951]). Conclusion We identified factors predictive of clinical symptoms in patients with convexity, parasagittal, and falx meningiomas and determined the first-ever threshold tumor volume for predicting symptomatic progression in such patients." @default.
• W3158954198 created "2021-05-10" @default.
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• W3158954198 date "2021-04-21" @default.
• W3158954198 modified "2023-09-26" @default.
• W3158954198 title "How much tumor volume is responsible for development of clinical symptoms in patients with convexity, parasagittal, and falx meningiomas?" @default.
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• W3158954198 doi "https://doi.org/10.21203/rs.3.rs-437289/v1" @default.
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