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- W3159042051 abstract "The radiomodulatory effect of guduchi extract (TCE) was studied in HeLa cells incubated with 0, 1, 2, 4, 6 or 8 µg/ml of TCE for 2 or 4 h before exposure to 0, 0.5, 1, 2, 3 or 4 Gy of g-radiation. The molecular DNA damage was assessed using alkaline comet assay, where DNA tail fragmentation olive tail moment (OTM) served as a measure of DNA damage. Exposure of HeLa cells to 0, 0.5, 1, 2, 3 or 4 Gy g-i€rays caused a dose-dependent rise in the OTM indicating an increase in the DNA damage at all post-irradiation times. Treatment of HeLa cells with different concentrations of TCE before irradiation increased the OTM significantly at different assessment times, when compared with the concurrent non-TCE treated irradiated control. The greatest DNA damage was observed in cells pretreated with 8 µg/ml TCE, which was approximately 10 folds higher at 16 h for all irradiation doses. The cellular DNA did not exhibit repair of lesions as the DNA damage increased constantly up to 16 h post-irradiation and remained unaltered thereafter. TCE increased the cell killing effects of radiation by increasing the DNA damage and could be an alterantive strategy during radiotherapy of tumors. Key words: HeLa cells, guduchi, DNA damage,radiation, cell survival." @default.
- W3159042051 created "2021-05-10" @default.
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- W3159042051 date "2011-07-30" @default.
- W3159042051 modified "2023-09-28" @default.
- W3159042051 title "Assessment of radiation-induced DNA damage by comet assay in cultured HeLa cells treated with guduchi (Tinospora cordifolia Miers) before exposure to different doses of g-radiation" @default.
- W3159042051 doi "https://doi.org/10.5897/rpb.9000003" @default.
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