FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159042968> ?p ?o ?g. }

• W3159042968 abstract "Abstract Background/Aims Haemophagocytic lymphohistiocytosis (HLH) is a syndrome characterised by the presence of severe uncontrolled systemic inflammation due the overproduction of inflammatory cytokines and macrophage activation. The majority of adult patients have secondary HLH, triggered by either infection, haematological malignancy or rheumatic disease. Early recognition and initiation of definitive treatment is of vital importance as HLH leads to multi-organ failure and death if left untreated, with mortality of up to 80% in some cohorts. Methods Under-recognition of the disease and vast differences in the management of patients with HLH between specialities have been common problems. To address this, a Rheumatology-led HLH multi-disciplinary team (MDT) meeting was established at University College London Hospital (UCLH) in 2018. The MDT includes physicians from Rheumatology, Infectious Disease, Haematology, Intensive Care, Nephrology and Neurology and feeds into the national HLH group HASC - HLH Across Specialty Collaboration. The MDT is now held bimonthly, discussing between 2 and 4 cases each meeting. The MDT functions as a decision-making tool, while providing consensus on patient management, including collaboration on how to access urgent HLH-directed treatments such as Anakinra for secondary care centres without access. It also serves as a unique learning opportunity for trainees from different disciplines. Results Since the introduction of the MDT the number of patients diagnosed with HLH at ULCH has increased from an average of 6 per year in 2014-2016 to 12 per year in 2018-2020. In the last two years we have seen improved survival from years 2017/18 to 2019/20 (Table 1); survival was approximately 30% in 2017 and 75% in 2019. P018 Table 1:Outcomes of patients diagnosed with HLH (using ICD codes D761 and D762) at University College London Hospital since 2005.YEARALIVEDECEASED200511200601201021201111201220201334201442201525201641201737201839201993202095 Conclusion We believe that the HLH MDT has directly contributed to these improvements by encouraging earlier recognition and subspeciality collaboration. We encourage other sites to adopt a multi-disciplinary approach to managing patients with HLH to promote awareness of the condition and improve patient outcomes. Disclosure D.R. Ludwig: None. J. Manson: None. A. Jones: None. S. Mackenzie: None. N. Mccann: None." @default.
• W3159042968 created "2021-05-10" @default.
• W3159042968 creator A5009440542 @default.
• W3159042968 creator A5057648880 @default.
• W3159042968 creator A5063224846 @default.
• W3159042968 creator A5070326638 @default.
• W3159042968 creator A5090667792 @default.
• W3159042968 date "2021-04-01" @default.
• W3159042968 modified "2023-09-27" @default.
• W3159042968 title "P018 Multi-disciplinary team management of haemophagocytic lymphohistiocytosis: improving patient outcomes in a central London teaching hospital" @default.
• W3159042968 doi "https://doi.org/10.1093/rheumatology/keab247.017" @default.
• W3159042968 hasPublicationYear "2021" @default.
• W3159042968 type Work @default.
• W3159042968 sameAs 3159042968 @default.
• W3159042968 citedByCount "0" @default.
• W3159042968 crossrefType "journal-article" @default.
• W3159042968 hasAuthorship W3159042968A5009440542 @default.
• W3159042968 hasAuthorship W3159042968A5057648880 @default.
• W3159042968 hasAuthorship W3159042968A5063224846 @default.
• W3159042968 hasAuthorship W3159042968A5070326638 @default.
• W3159042968 hasAuthorship W3159042968A5090667792 @default.
• W3159042968 hasBestOaLocation W31590429681 @default.
• W3159042968 hasConcept C126322002 @default.
• W3159042968 hasConcept C177713679 @default.
• W3159042968 hasConcept C187212893 @default.
• W3159042968 hasConcept C194409129 @default.
• W3159042968 hasConcept C198451711 @default.
• W3159042968 hasConcept C20387591 @default.
• W3159042968 hasConcept C2779079688 @default.
• W3159042968 hasConcept C2779134260 @default.
• W3159042968 hasConcept C2779613421 @default.
• W3159042968 hasConcept C2781228260 @default.
• W3159042968 hasConcept C512399662 @default.
• W3159042968 hasConcept C54847362 @default.
• W3159042968 hasConcept C71924100 @default.
• W3159042968 hasConceptScore W3159042968C126322002 @default.
• W3159042968 hasConceptScore W3159042968C177713679 @default.
• W3159042968 hasConceptScore W3159042968C187212893 @default.
• W3159042968 hasConceptScore W3159042968C194409129 @default.
• W3159042968 hasConceptScore W3159042968C198451711 @default.
• W3159042968 hasConceptScore W3159042968C20387591 @default.
• W3159042968 hasConceptScore W3159042968C2779079688 @default.
• W3159042968 hasConceptScore W3159042968C2779134260 @default.
• W3159042968 hasConceptScore W3159042968C2779613421 @default.
• W3159042968 hasConceptScore W3159042968C2781228260 @default.
• W3159042968 hasConceptScore W3159042968C512399662 @default.
• W3159042968 hasConceptScore W3159042968C54847362 @default.
• W3159042968 hasConceptScore W3159042968C71924100 @default.
• W3159042968 hasIssue "Supplement_1" @default.
• W3159042968 hasLocation W31590429681 @default.
• W3159042968 hasOpenAccess W3159042968 @default.
• W3159042968 hasPrimaryLocation W31590429681 @default.
• W3159042968 hasRelatedWork W2043681183 @default.
• W3159042968 hasRelatedWork W2076186742 @default.
• W3159042968 hasRelatedWork W2088413152 @default.
• W3159042968 hasRelatedWork W2090668142 @default.
• W3159042968 hasRelatedWork W2094652038 @default.
• W3159042968 hasRelatedWork W2114702694 @default.
• W3159042968 hasRelatedWork W2802274402 @default.
• W3159042968 hasRelatedWork W2973124663 @default.
• W3159042968 hasRelatedWork W4307901253 @default.
• W3159042968 hasRelatedWork W4321376684 @default.
• W3159042968 hasVolume "60" @default.
• W3159042968 isParatext "false" @default.
• W3159042968 isRetracted "false" @default.
• W3159042968 magId "3159042968" @default.
• W3159042968 workType "article" @default.