SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159068051> ?p ?o ?g. }

Showing items 1 to 100 of ±140 with 100 items per page.

W3159068051 endingPage "3679" @default.
W3159068051 startingPage "3665" @default.
W3159068051 abstract "Abstract Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG) can serve as an effective and safe pharmacological target in a syngeneic murine model. AREG is highly abundant in abdominal fluids of patients with advanced OvCa. In immunocompetent animals, depletion or overexpression of AREG respectively prolonged or shortened animal survival. A new antibody we generated in AREG-knockout mice recognized murine AREG and reproducibly prolonged animal survival in the syngeneic model. The underlying mechanism likely involves binding of wildtype p53 to AREG ’s promoter and autocrine activation of the epidermal growth factor receptor (EGFR), a step blocked by the antibody. Accordingly, depletion of p53 downregulated AREG secretion and conferred tolerance, whereas blocking an adaptive process involving CXCL1, which transactivates EGFR, might increase therapeutic efficacy. Consistent with these observations, analysis of OvCa patients revealed that high AREG correlates with poor prognosis of patients expressing wildtype TP53 . In conclusion, clinical tests of the novel antibody are warranted; high AREG, normal TP53 , and reduced CXCL1 activity might identify patients with OvCa who may derive therapeutic benefit." @default.
W3159068051 created "2021-05-10" @default.
W3159068051 creator A5003912416 @default.
W3159068051 creator A5011594133 @default.
W3159068051 creator A5020936720 @default.
W3159068051 creator A5021728662 @default.
W3159068051 creator A5023390854 @default.
W3159068051 creator A5034212588 @default.
W3159068051 creator A5037646314 @default.
W3159068051 creator A5050727904 @default.
W3159068051 creator A5053194803 @default.
W3159068051 creator A5056792934 @default.
W3159068051 creator A5065415800 @default.
W3159068051 creator A5077837763 @default.
W3159068051 creator A5084328988 @default.
W3159068051 creator A5087071423 @default.
W3159068051 creator A5089242165 @default.
W3159068051 date "2021-04-30" @default.
W3159068051 modified "2023-10-02" @default.
W3159068051 title "Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53" @default.
W3159068051 cites W1758302002 @default.
W3159068051 cites W1901316412 @default.
W3159068051 cites W1965211843 @default.
W3159068051 cites W1984469163 @default.
W3159068051 cites W1987720155 @default.
W3159068051 cites W1993060180 @default.
W3159068051 cites W1993219448 @default.
W3159068051 cites W2012315119 @default.
W3159068051 cites W2018221147 @default.
W3159068051 cites W2019917670 @default.
W3159068051 cites W2026576172 @default.
W3159068051 cites W2033670530 @default.
W3159068051 cites W2039921156 @default.
W3159068051 cites W2069105390 @default.
W3159068051 cites W2076327296 @default.
W3159068051 cites W2121406339 @default.
W3159068051 cites W2128932369 @default.
W3159068051 cites W2136546686 @default.
W3159068051 cites W2137309994 @default.
W3159068051 cites W2143633028 @default.
W3159068051 cites W2151328705 @default.
W3159068051 cites W2154870995 @default.
W3159068051 cites W2158734599 @default.
W3159068051 cites W2161696113 @default.
W3159068051 cites W2164401185 @default.
W3159068051 cites W2168213749 @default.
W3159068051 cites W2170928115 @default.
W3159068051 cites W2171182747 @default.
W3159068051 cites W2171249989 @default.
W3159068051 cites W2513362995 @default.
W3159068051 cites W2592811885 @default.
W3159068051 cites W2751489395 @default.
W3159068051 cites W2769136370 @default.
W3159068051 cites W2782951594 @default.
W3159068051 cites W2794422249 @default.
W3159068051 cites W4211162417 @default.
W3159068051 doi "https://doi.org/10.1038/s41388-021-01784-8" @default.
W3159068051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8154589" @default.
W3159068051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33941851" @default.
W3159068051 hasPublicationYear "2021" @default.
W3159068051 type Work @default.
W3159068051 sameAs 3159068051 @default.
W3159068051 citedByCount "7" @default.
W3159068051 countsByYear W31590680512021 @default.
W3159068051 countsByYear W31590680512022 @default.
W3159068051 countsByYear W31590680512023 @default.
W3159068051 crossrefType "journal-article" @default.
W3159068051 hasAuthorship W3159068051A5003912416 @default.
W3159068051 hasAuthorship W3159068051A5011594133 @default.
W3159068051 hasAuthorship W3159068051A5020936720 @default.
W3159068051 hasAuthorship W3159068051A5021728662 @default.
W3159068051 hasAuthorship W3159068051A5023390854 @default.
W3159068051 hasAuthorship W3159068051A5034212588 @default.
W3159068051 hasAuthorship W3159068051A5037646314 @default.
W3159068051 hasAuthorship W3159068051A5050727904 @default.
W3159068051 hasAuthorship W3159068051A5053194803 @default.
W3159068051 hasAuthorship W3159068051A5056792934 @default.
W3159068051 hasAuthorship W3159068051A5065415800 @default.
W3159068051 hasAuthorship W3159068051A5077837763 @default.
W3159068051 hasAuthorship W3159068051A5084328988 @default.
W3159068051 hasAuthorship W3159068051A5087071423 @default.
W3159068051 hasAuthorship W3159068051A5089242165 @default.
W3159068051 hasBestOaLocation W31590680511 @default.
W3159068051 hasConcept C121608353 @default.
W3159068051 hasConcept C126322002 @default.
W3159068051 hasConcept C128240485 @default.
W3159068051 hasConcept C13373296 @default.
W3159068051 hasConcept C170493617 @default.
W3159068051 hasConcept C203014093 @default.
W3159068051 hasConcept C2779438470 @default.
W3159068051 hasConcept C2780140570 @default.
W3159068051 hasConcept C2780427987 @default.
W3159068051 hasConcept C2780806702 @default.
W3159068051 hasConcept C502942594 @default.
W3159068051 hasConcept C54355233 @default.
W3159068051 hasConcept C55493867 @default.
W3159068051 hasConcept C71924100 @default.
W3159068051 hasConcept C86803240 @default.