FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159089622> ?p ?o ?g. }

• W3159089622 endingPage "151508" @default.
• W3159089622 startingPage "151508" @default.
• W3159089622 abstract "Salmonella is a leading cause of foodborne pathogen which causes intestinal and systemic diseases across the world. Vaccination is the most effective protection against Salmonella, but the identification and design of an effective broad-spectrum vaccine is still a great challenge, because of the multi-serotypes of Salmonella. Reverse vaccinology is a new tool to discovery and design vaccine antigens combining human immunology, structural biology and computational biology with microbial genomics. In this study, reverse vaccinology, an in-silico approach was established to screen appropriate immunogen targets by calculating the immunogenicity score of 583 non-redundant outer membrane and secreted proteins of Salmonella. Herein among 100 proteins identified with top-ranked scores, 15 representative antigens were selected randomly. Applying the sequence conservation test, four proteins (FliK, BcsZ, FhuA and FepA) remained as potential vaccine candidates for in vivo evaluation of immunogenicity and immunoprotection. All four candidates were capable to trigger the immune response and stimulate the production of antiserum in mice. Furthermore, top-ranked proteins including FliK and BcsZ provided wide antigenic coverage among the multi-serotype of Salmonella. The S. Typhimurium LT2 challenge model used in mice immunized with FliK and BcsZ showed a high relative percentage survival (RPS) of 52.74 % and 64.71 % respectively. In conclusion, this study constructed an in-silico pipeline able to successfully pre-screen the vaccine targets characterized by high immunogenicity and protective immunity. We show that reverse vaccinology allowed screening of appropriate broad-spectrum vaccines for Salmonella." @default.
• W3159089622 created "2021-05-10" @default.
• W3159089622 creator A5017941291 @default.
• W3159089622 creator A5023778219 @default.
• W3159089622 creator A5026984704 @default.
• W3159089622 creator A5061840111 @default.
• W3159089622 creator A5073114978 @default.
• W3159089622 creator A5075989197 @default.
• W3159089622 creator A5083177546 @default.
• W3159089622 date "2021-07-01" @default.
• W3159089622 modified "2023-10-16" @default.
• W3159089622 title "Reverse vaccinology approach for the identifications of potential vaccine candidates against Salmonella" @default.
• W3159089622 cites W1487786274 @default.
• W3159089622 cites W1520065624 @default.
• W3159089622 cites W1920578382 @default.
• W3159089622 cites W1979640744 @default.
• W3159089622 cites W1991860284 @default.
• W3159089622 cites W1995690087 @default.
• W3159089622 cites W2005380527 @default.
• W3159089622 cites W2009009845 @default.
• W3159089622 cites W2021434418 @default.
• W3159089622 cites W2021508781 @default.
• W3159089622 cites W2027263004 @default.
• W3159089622 cites W2053707749 @default.
• W3159089622 cites W2062001398 @default.
• W3159089622 cites W2064897680 @default.
• W3159089622 cites W2071484066 @default.
• W3159089622 cites W2078896359 @default.
• W3159089622 cites W2083236595 @default.
• W3159089622 cites W2097606916 @default.
• W3159089622 cites W2101997581 @default.
• W3159089622 cites W2114692326 @default.
• W3159089622 cites W2118943119 @default.
• W3159089622 cites W2124672930 @default.
• W3159089622 cites W2125065061 @default.
• W3159089622 cites W2135623402 @default.
• W3159089622 cites W2138815567 @default.
• W3159089622 cites W2140971235 @default.
• W3159089622 cites W2156039063 @default.
• W3159089622 cites W2159838688 @default.
• W3159089622 cites W2171740232 @default.
• W3159089622 cites W2180566168 @default.
• W3159089622 cites W2537889934 @default.
• W3159089622 cites W2567899704 @default.
• W3159089622 cites W2590085129 @default.
• W3159089622 cites W2592353487 @default.
• W3159089622 cites W2607169459 @default.
• W3159089622 cites W2611314002 @default.
• W3159089622 cites W2620295621 @default.
• W3159089622 cites W2752784701 @default.
• W3159089622 cites W2802551462 @default.
• W3159089622 cites W2911791149 @default.
• W3159089622 cites W2920820655 @default.
• W3159089622 cites W2923647077 @default.
• W3159089622 cites W2953065444 @default.
• W3159089622 cites W2967553667 @default.
• W3159089622 cites W4231722547 @default.
• W3159089622 doi "https://doi.org/10.1016/j.ijmm.2021.151508" @default.
• W3159089622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34182206" @default.
• W3159089622 hasPublicationYear "2021" @default.
• W3159089622 type Work @default.
• W3159089622 sameAs 3159089622 @default.
• W3159089622 citedByCount "14" @default.
• W3159089622 countsByYear W31590896222021 @default.
• W3159089622 countsByYear W31590896222022 @default.
• W3159089622 countsByYear W31590896222023 @default.
• W3159089622 crossrefType "journal-article" @default.
• W3159089622 hasAuthorship W3159089622A5017941291 @default.
• W3159089622 hasAuthorship W3159089622A5023778219 @default.
• W3159089622 hasAuthorship W3159089622A5026984704 @default.
• W3159089622 hasAuthorship W3159089622A5061840111 @default.
• W3159089622 hasAuthorship W3159089622A5073114978 @default.
• W3159089622 hasAuthorship W3159089622A5075989197 @default.
• W3159089622 hasAuthorship W3159089622A5083177546 @default.
• W3159089622 hasBestOaLocation W31590896221 @default.
• W3159089622 hasConcept C147483822 @default.
• W3159089622 hasConcept C159047783 @default.
• W3159089622 hasConcept C195616568 @default.
• W3159089622 hasConcept C203014093 @default.
• W3159089622 hasConcept C2781065037 @default.
• W3159089622 hasConcept C2781152039 @default.
• W3159089622 hasConcept C523546767 @default.
• W3159089622 hasConcept C54355233 @default.
• W3159089622 hasConcept C70721500 @default.
• W3159089622 hasConcept C86803240 @default.
• W3159089622 hasConceptScore W3159089622C147483822 @default.
• W3159089622 hasConceptScore W3159089622C159047783 @default.
• W3159089622 hasConceptScore W3159089622C195616568 @default.
• W3159089622 hasConceptScore W3159089622C203014093 @default.
• W3159089622 hasConceptScore W3159089622C2781065037 @default.
• W3159089622 hasConceptScore W3159089622C2781152039 @default.
• W3159089622 hasConceptScore W3159089622C523546767 @default.
• W3159089622 hasConceptScore W3159089622C54355233 @default.
• W3159089622 hasConceptScore W3159089622C70721500 @default.
• W3159089622 hasConceptScore W3159089622C86803240 @default.
• W3159089622 hasFunder F4320324854 @default.
• W3159089622 hasIssue "5" @default.
• W3159089622 hasLocation W31590896221 @default.

• next