FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159093179> ?p ?o ?g. }

• W3159093179 abstract "Antimicrobial resistance (AMR) is a pressing global health crisis, which has been fuelled by the sustained use of certain classes of antimicrobials, including fluoroquinolones. While the genetic mutations responsible for decreased fluoroquinolone (ciprofloxacin) susceptibility are known, the implications of ciprofloxacin exposure on bacterial growth, survival, and interactions with host cells are not well described. Aiming to understand the influence of inhibitory concentrations of ciprofloxacin in vitro, we subjected three clinical isolates of S. Typhimurium to differing concentrations of ciprofloxacin, dependent on their minimum inhibitory concentrations (MIC), and assessed the impact on bacterial growth, morphology, and transcription. We further investigated the differential morphology and transcription that occurred following ciprofloxacin exposure and measured the ability of ciprofloxacin-treated bacteria to invade and replicate in host cells. We found that ciprofloxacin-exposed S. Typhimurium are able to recover from inhibitory concentrations of ciprofloxacin, and that the drug induces specific morphological and transcriptional signatures associated with the bacterial SOS response, DNA repair, and intracellular survival. In addition, ciprofloxacin-treated S. Typhimurium have increased capacity for intracellular replication in comparison to untreated organisms. These data suggest that S. Typhimurium undergoes an adaptive response under ciprofloxacin perturbation that promotes cellular survival, a consequence that may justify more measured use of ciprofloxacin for Salmonella infections. The combination of multiple experimental approaches provides new insights into the collateral effects that ciprofloxacin and other antimicrobials have on invasive bacterial pathogens." @default.
• W3159093179 created "2021-05-10" @default.
• W3159093179 creator A5018319045 @default.
• W3159093179 creator A5025001160 @default.
• W3159093179 creator A5028534327 @default.
• W3159093179 creator A5032122956 @default.
• W3159093179 creator A5038603184 @default.
• W3159093179 creator A5054682524 @default.
• W3159093179 creator A5072515919 @default.
• W3159093179 creator A5085874523 @default.
• W3159093179 date "2021-05-07" @default.
• W3159093179 modified "2023-10-16" @default.
• W3159093179 title "Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of Salmonella Typhimurium" @default.
• W3159093179 cites W1523862750 @default.
• W3159093179 cites W1525153459 @default.
• W3159093179 cites W1587026990 @default.
• W3159093179 cites W1965511397 @default.
• W3159093179 cites W1966090691 @default.
• W3159093179 cites W1966783360 @default.
• W3159093179 cites W1967798600 @default.
• W3159093179 cites W1969244937 @default.
• W3159093179 cites W1971563274 @default.
• W3159093179 cites W1977112674 @default.
• W3159093179 cites W1979333735 @default.
• W3159093179 cites W1984171637 @default.
• W3159093179 cites W2031010426 @default.
• W3159093179 cites W2031223726 @default.
• W3159093179 cites W2040445226 @default.
• W3159093179 cites W2042048278 @default.
• W3159093179 cites W2046131957 @default.
• W3159093179 cites W2048866059 @default.
• W3159093179 cites W2049275403 @default.
• W3159093179 cites W2054440815 @default.
• W3159093179 cites W2055278523 @default.
• W3159093179 cites W2061878956 @default.
• W3159093179 cites W2066073054 @default.
• W3159093179 cites W2070068738 @default.
• W3159093179 cites W2112181946 @default.
• W3159093179 cites W2127313002 @default.
• W3159093179 cites W2129386228 @default.
• W3159093179 cites W2129887751 @default.
• W3159093179 cites W2132337346 @default.
• W3159093179 cites W2132530250 @default.
• W3159093179 cites W2139649460 @default.
• W3159093179 cites W2148323109 @default.
• W3159093179 cites W2157007438 @default.
• W3159093179 cites W2171296640 @default.
• W3159093179 cites W2179438025 @default.
• W3159093179 cites W2337587373 @default.
• W3159093179 cites W2586691160 @default.
• W3159093179 cites W2592248586 @default.
• W3159093179 cites W2605004684 @default.
• W3159093179 cites W2622731166 @default.
• W3159093179 cites W2624701244 @default.
• W3159093179 cites W2736010438 @default.
• W3159093179 cites W2748777487 @default.
• W3159093179 cites W2754707073 @default.
• W3159093179 cites W2761578385 @default.
• W3159093179 cites W2779019546 @default.
• W3159093179 cites W2782087918 @default.
• W3159093179 cites W2788069949 @default.
• W3159093179 cites W2801239041 @default.
• W3159093179 cites W2804492322 @default.
• W3159093179 cites W2805077736 @default.
• W3159093179 cites W2884849385 @default.
• W3159093179 cites W2890599573 @default.
• W3159093179 cites W2905535015 @default.
• W3159093179 cites W2924530200 @default.
• W3159093179 cites W2947817214 @default.
• W3159093179 cites W2964086819 @default.
• W3159093179 cites W2967842116 @default.
• W3159093179 cites W2974739260 @default.
• W3159093179 cites W2982187729 @default.
• W3159093179 cites W3000372921 @default.
• W3159093179 cites W3003180447 @default.
• W3159093179 cites W3008111131 @default.
• W3159093179 cites W3014196972 @default.
• W3159093179 cites W3033297836 @default.
• W3159093179 cites W3044729281 @default.
• W3159093179 cites W31581040 @default.
• W3159093179 cites W3210926305 @default.
• W3159093179 doi "https://doi.org/10.1101/2021.05.06.443048" @default.
• W3159093179 hasPublicationYear "2021" @default.
• W3159093179 type Work @default.
• W3159093179 sameAs 3159093179 @default.
• W3159093179 citedByCount "1" @default.
• W3159093179 countsByYear W31590931792022 @default.
• W3159093179 crossrefType "posted-content" @default.
• W3159093179 hasAuthorship W3159093179A5018319045 @default.
• W3159093179 hasAuthorship W3159093179A5025001160 @default.
• W3159093179 hasAuthorship W3159093179A5028534327 @default.
• W3159093179 hasAuthorship W3159093179A5032122956 @default.
• W3159093179 hasAuthorship W3159093179A5038603184 @default.
• W3159093179 hasAuthorship W3159093179A5054682524 @default.
• W3159093179 hasAuthorship W3159093179A5072515919 @default.
• W3159093179 hasAuthorship W3159093179A5085874523 @default.
• W3159093179 hasBestOaLocation W31590931791 @default.
• W3159093179 hasConcept C176947019 @default.
• W3159093179 hasConcept C2778512257 @default.
• W3159093179 hasConcept C2781065037 @default.

• next