Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159098178> ?p ?o ?g. }
- W3159098178 endingPage "101004" @default.
- W3159098178 startingPage "101004" @default.
- W3159098178 abstract "Serpinb1a, a serine protease inhibitor family protein, has been implicated in immunoregulation and several metabolic disorders, such as diabetes and obesity; however, its roles in bone remain unknown. Therefore, we herein investigated the physiological functions of Serpinb1a in osteoclastic and osteoblastic differentiation using mouse cell lines. Serpinb1a overexpression markedly reduced the number of tartrate-resistant acid phosphatase (TRAP)- and calcitonin receptor-positive multinucleated cells increased by receptor activator nuclear factor κB ligand (RANKL) in mouse preosteoclastic RAW 264.7 cells. Moreover, it significantly decreased the mRNA levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), TRAP and cathepsin K in these cells. Regarding osteoblasts, Serpinb1a overexpression significantly reduced the mRNA levels of alkaline phosphatase (ALP) and osteocalcin as well as ALP activity induced by bone morphogenetic protein-2 (BMP-2) in mouse mesenchymal ST2 cells, although it did not alter osteoblast differentiation in mouse osteoblastic MC3T3-E1 cells. Concerning the pathophysiological relevance of Serpinb1a, Serpinb1a mRNA levels were decreased in the soleus and gastrocnemius muscles of mice 4 weeks after bilateral sciatic nerve resection. In conclusion, we herein revealed for the first time that Serpinb1a inhibited osteoclast formation induced by RANKL in RAW 264.7 cells and suppressed BMP-2-induced ALP activity in ST2 cells." @default.
- W3159098178 created "2021-05-10" @default.
- W3159098178 creator A5010946256 @default.
- W3159098178 creator A5016743453 @default.
- W3159098178 creator A5027825480 @default.
- W3159098178 creator A5049639478 @default.
- W3159098178 creator A5084929040 @default.
- W3159098178 date "2021-07-01" @default.
- W3159098178 modified "2023-10-16" @default.
- W3159098178 title "Serpinb1a suppresses osteoclast formation" @default.
- W3159098178 cites W1972377079 @default.
- W3159098178 cites W2018705773 @default.
- W3159098178 cites W2026281047 @default.
- W3159098178 cites W2040500344 @default.
- W3159098178 cites W2066293933 @default.
- W3159098178 cites W2075530608 @default.
- W3159098178 cites W2078759546 @default.
- W3159098178 cites W2093252878 @default.
- W3159098178 cites W2095053527 @default.
- W3159098178 cites W2120748106 @default.
- W3159098178 cites W2122367477 @default.
- W3159098178 cites W2122987234 @default.
- W3159098178 cites W2149900898 @default.
- W3159098178 cites W2150355474 @default.
- W3159098178 cites W2171215167 @default.
- W3159098178 cites W2175125313 @default.
- W3159098178 cites W2221658929 @default.
- W3159098178 cites W2233405491 @default.
- W3159098178 cites W2327333766 @default.
- W3159098178 cites W2417621470 @default.
- W3159098178 cites W2462743167 @default.
- W3159098178 cites W2510762761 @default.
- W3159098178 cites W2519083883 @default.
- W3159098178 cites W2554815865 @default.
- W3159098178 cites W2566072331 @default.
- W3159098178 cites W2600929274 @default.
- W3159098178 cites W2784210182 @default.
- W3159098178 cites W2790016534 @default.
- W3159098178 cites W2791012513 @default.
- W3159098178 cites W2804452595 @default.
- W3159098178 cites W2865323408 @default.
- W3159098178 cites W2890469987 @default.
- W3159098178 cites W2892323781 @default.
- W3159098178 cites W2899136048 @default.
- W3159098178 cites W2919190158 @default.
- W3159098178 cites W2949795425 @default.
- W3159098178 cites W3010342128 @default.
- W3159098178 cites W3109277150 @default.
- W3159098178 doi "https://doi.org/10.1016/j.bbrep.2021.101004" @default.
- W3159098178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8100536" @default.
- W3159098178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33997318" @default.
- W3159098178 hasPublicationYear "2021" @default.
- W3159098178 type Work @default.
- W3159098178 sameAs 3159098178 @default.
- W3159098178 citedByCount "2" @default.
- W3159098178 countsByYear W31590981782022 @default.
- W3159098178 countsByYear W31590981782023 @default.
- W3159098178 crossrefType "journal-article" @default.
- W3159098178 hasAuthorship W3159098178A5010946256 @default.
- W3159098178 hasAuthorship W3159098178A5016743453 @default.
- W3159098178 hasAuthorship W3159098178A5027825480 @default.
- W3159098178 hasAuthorship W3159098178A5049639478 @default.
- W3159098178 hasAuthorship W3159098178A5084929040 @default.
- W3159098178 hasBestOaLocation W31590981781 @default.
- W3159098178 hasConcept C101990758 @default.
- W3159098178 hasConcept C118303440 @default.
- W3159098178 hasConcept C126322002 @default.
- W3159098178 hasConcept C131075544 @default.
- W3159098178 hasConcept C134018914 @default.
- W3159098178 hasConcept C136403682 @default.
- W3159098178 hasConcept C160160445 @default.
- W3159098178 hasConcept C163170386 @default.
- W3159098178 hasConcept C167844969 @default.
- W3159098178 hasConcept C170493617 @default.
- W3159098178 hasConcept C181199279 @default.
- W3159098178 hasConcept C185592680 @default.
- W3159098178 hasConcept C198826908 @default.
- W3159098178 hasConcept C202751555 @default.
- W3159098178 hasConcept C2776033226 @default.
- W3159098178 hasConcept C2778260815 @default.
- W3159098178 hasConcept C2779428903 @default.
- W3159098178 hasConcept C55493867 @default.
- W3159098178 hasConcept C71924100 @default.
- W3159098178 hasConcept C86803240 @default.
- W3159098178 hasConcept C88045685 @default.
- W3159098178 hasConcept C92316933 @default.
- W3159098178 hasConcept C95444343 @default.
- W3159098178 hasConceptScore W3159098178C101990758 @default.
- W3159098178 hasConceptScore W3159098178C118303440 @default.
- W3159098178 hasConceptScore W3159098178C126322002 @default.
- W3159098178 hasConceptScore W3159098178C131075544 @default.
- W3159098178 hasConceptScore W3159098178C134018914 @default.
- W3159098178 hasConceptScore W3159098178C136403682 @default.
- W3159098178 hasConceptScore W3159098178C160160445 @default.
- W3159098178 hasConceptScore W3159098178C163170386 @default.
- W3159098178 hasConceptScore W3159098178C167844969 @default.
- W3159098178 hasConceptScore W3159098178C170493617 @default.
- W3159098178 hasConceptScore W3159098178C181199279 @default.