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• W3159098866 abstract "Introduction: Animal models have been widely used to investigate the etiology and potential treatments for diabetic peripheral neuropathy. What we have learned from these studies and the extent to which this information has been adapted for the human condition will be the subject of this review article. Methods: A comprehensive search of the PubMed database was performed, and relevant articles on the topic were included in this review. Results: Extensive study of diabetic animal models has shown that the etiology of diabetic peripheral neuropathy is complex, with multiple mechanisms affecting neurons, Schwann cells, and the microvasculature, which contribute to the phenotypic nature of this most common complication of diabetes. Moreover, animal studies have demonstrated that the mechanisms related to peripheral neuropathy occurring in type 1 and type 2 diabetes are likely different, with hyperglycemia being the primary factor for neuropathology in type 1 diabetes, which contributes to a lesser extent in type 2 diabetes, whereas insulin resistance, hyperlipidemia, and other factors may have a greater role. Two of the earliest mechanisms described from animal studies as a cause for diabetic peripheral neuropathy were the activation of the aldose reductase pathway and increased non-enzymatic glycation. However, continuing research has identified numerous other potential factors that may contribute to diabetic peripheral neuropathy, including oxidative and inflammatory stress, dysregulation of protein kinase C and hexosamine pathways, and decreased neurotrophic support. In addition, recent studies have demonstrated that peripheral neuropathy-like symptoms are present in animal models, representing pre-diabetes in the absence of hyperglycemia. Conclusions: This complexity complicates the successful treatment of diabetic peripheral neuropathy, and results in the poor outcome of translating successful treatments from animal studies to human clinical trials." @default.
• W3159098866 created "2021-05-10" @default.
• W3159098866 creator A5082694775 @default.
• W3159098866 date "2022-06-01" @default.
• W3159098866 modified "2023-10-18" @default.
• W3159098866 title "Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?" @default.
• W3159098866 cites W1494247371 @default.
• W3159098866 cites W1529592271 @default.
• W3159098866 cites W1534136821 @default.
• W3159098866 cites W1559303041 @default.
• W3159098866 cites W1611811727 @default.
• W3159098866 cites W1831581079 @default.
• W3159098866 cites W1861262597 @default.
• W3159098866 cites W1899624445 @default.
• W3159098866 cites W1904061758 @default.
• W3159098866 cites W1964991169 @default.
• W3159098866 cites W1966059010 @default.
• W3159098866 cites W1967724716 @default.
• W3159098866 cites W1967729440 @default.
• W3159098866 cites W1968813770 @default.
• W3159098866 cites W1969953290 @default.
• W3159098866 cites W1970945844 @default.
• W3159098866 cites W1972009778 @default.
• W3159098866 cites W1973943724 @default.
• W3159098866 cites W1974791259 @default.
• W3159098866 cites W1975234751 @default.
• W3159098866 cites W1975317413 @default.
• W3159098866 cites W1976065525 @default.
• W3159098866 cites W1976422365 @default.
• W3159098866 cites W1978056298 @default.
• W3159098866 cites W1978827631 @default.
• W3159098866 cites W1979517872 @default.
• W3159098866 cites W1979869319 @default.
• W3159098866 cites W1980401819 @default.
• W3159098866 cites W1981058102 @default.
• W3159098866 cites W1983997832 @default.
• W3159098866 cites W1985109666 @default.
• W3159098866 cites W1985712620 @default.
• W3159098866 cites W1985977889 @default.
• W3159098866 cites W1987124008 @default.
• W3159098866 cites W1987191170 @default.
• W3159098866 cites W1989525211 @default.
• W3159098866 cites W1992457015 @default.
• W3159098866 cites W1993480354 @default.
• W3159098866 cites W1994895968 @default.
• W3159098866 cites W1995556010 @default.
• W3159098866 cites W1996424575 @default.
• W3159098866 cites W1996626960 @default.
• W3159098866 cites W1998060298 @default.
• W3159098866 cites W1998614770 @default.
• W3159098866 cites W2000389046 @default.
• W3159098866 cites W2001489721 @default.
• W3159098866 cites W2002501352 @default.
• W3159098866 cites W2002607374 @default.
• W3159098866 cites W2002670155 @default.
• W3159098866 cites W2002959870 @default.
• W3159098866 cites W2004001185 @default.
• W3159098866 cites W2006728188 @default.
• W3159098866 cites W2007880055 @default.
• W3159098866 cites W2009340697 @default.
• W3159098866 cites W2011595187 @default.
• W3159098866 cites W2012145101 @default.
• W3159098866 cites W2012753407 @default.
• W3159098866 cites W2012852638 @default.
• W3159098866 cites W2016389270 @default.
• W3159098866 cites W2017612549 @default.
• W3159098866 cites W2018548020 @default.
• W3159098866 cites W2020979704 @default.
• W3159098866 cites W2022830342 @default.
• W3159098866 cites W2023217835 @default.
• W3159098866 cites W2024190844 @default.
• W3159098866 cites W2025315091 @default.
• W3159098866 cites W2026940981 @default.
• W3159098866 cites W2028214220 @default.
• W3159098866 cites W2030053126 @default.
• W3159098866 cites W2031980199 @default.
• W3159098866 cites W2033378879 @default.
• W3159098866 cites W2034289205 @default.
• W3159098866 cites W2034446363 @default.
• W3159098866 cites W2037682503 @default.
• W3159098866 cites W2039399774 @default.
• W3159098866 cites W2040766716 @default.
• W3159098866 cites W2042030474 @default.
• W3159098866 cites W2044333192 @default.
• W3159098866 cites W2044437167 @default.
• W3159098866 cites W2045232429 @default.
• W3159098866 cites W2047157458 @default.
• W3159098866 cites W2048421592 @default.
• W3159098866 cites W2057676556 @default.
• W3159098866 cites W2062548885 @default.
• W3159098866 cites W2062967780 @default.
• W3159098866 cites W2064573161 @default.
• W3159098866 cites W2065218028 @default.
• W3159098866 cites W2065276108 @default.
• W3159098866 cites W2066190773 @default.
• W3159098866 cites W2066779642 @default.
• W3159098866 cites W2067845216 @default.
• W3159098866 cites W2070763907 @default.
• W3159098866 cites W2071667426 @default.
• W3159098866 cites W2073715063 @default.

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