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- W3159109223 abstract "Universities worldwide are establishing drug discovery centers to facilitate translation of exciting new human disease biology into therapeutic modalities. Drug hunting activities are typically focused on lead finding (high-throughput screening) coupled with some measure of chemical and pharmacokinetic optimization. Ideally, the research yields novel, selective drug-like molecules suitable for in vivo proof-of-concept studies and preclinical drug target validation. Preclinical activities are increasingly conducted in partnership with a pharmaceutical company seeking to access and supplement their drug development pipeline. Perpetually striving to gain a competitive edge and enhance efficiency, productivity, and profitability, the pharma industry is simultaneously experimenting with open- and crowd-source platforms and innovation incubators. Both enterprises, therefore, benefit from each other. This article is composed of a series of contributions (vignettes) from eight academic centers in the United States, the United Kingdom, Sweden, and Japan and one US-based pharmaceutical company (Table 2). The perspectives cover a range of topics including the rise of academic drug discovery and public–private partnerships; mission, objectives, and evolution of a particular center; resourcing; performance metrics; strategic and tactical lessons learned; attributes of successful projects; and open innovation initiatives. The accounts are punctuated with case studies to illustrate collective inventive capabilities." @default.
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- W3159109223 date "2021-04-28" @default.
- W3159109223 modified "2023-10-16" @default.
- W3159109223 title "Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery" @default.
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