Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159115906> ?p ?o ?g. }
- W3159115906 abstract "Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Although standard-of-care chemotherapeutics are sufficient for most ALL cases, there are subsets of patients with poor response who relapse in disease. The biology underlying differences between subtypes and their response to therapy has only partially been explained by genetic and transcriptomic profiling. To characterize ALL subtypes and identify novel pharmacologic vulnerabilities, we performed comprehensive multi-omic analyses of 49 widely-used childhood ALL cell lines, using proteomics, transcriptomics, and pharmacoproteomic characterization. This enabled us to characterize the functional impact of genetic fusions and cellular differentiation states. The proteomics data revealed differences in spliceosome and p53 levels not evident in the transcriptomics data and with improved correlation to drug sensitivity. Focusing on BCP-ALL cell lines, we connected the genotype, molecular phenotype, and functional phenotype with drug response data on 528 oncology drugs. Here, we identified the DAG-analog Bryostatin-1 as a novel therapeutic candidate in the MEF2D-HNRNPUL1 fusion high-risk subtype, for which this drug activated pro-apoptotic ERK signaling associated with molecular mediators of pre-B cell negative selection. Our data also forms an interactive online resource with navigable proteomics, transcriptomics, and drug sensitivity profiles at https://lehtio-lab.se/forall/." @default.
- W3159115906 created "2021-05-10" @default.
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- W3159115906 date "2021-04-29" @default.
- W3159115906 modified "2023-10-01" @default.
- W3159115906 title "Multi-omics molecular phenotyping of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilities" @default.
- W3159115906 cites W1541517259 @default.
- W3159115906 cites W1569503463 @default.
- W3159115906 cites W1576233656 @default.
- W3159115906 cites W1916983144 @default.
- W3159115906 cites W1944989862 @default.
- W3159115906 cites W1975764660 @default.
- W3159115906 cites W1976023782 @default.
- W3159115906 cites W1980528204 @default.
- W3159115906 cites W1983646042 @default.
- W3159115906 cites W1984065010 @default.
- W3159115906 cites W1985579610 @default.
- W3159115906 cites W1987446594 @default.
- W3159115906 cites W1988163167 @default.
- W3159115906 cites W1996022168 @default.
- W3159115906 cites W2001499276 @default.
- W3159115906 cites W2004208753 @default.
- W3159115906 cites W2005471059 @default.
- W3159115906 cites W2016833582 @default.
- W3159115906 cites W2018658509 @default.
- W3159115906 cites W2021267652 @default.
- W3159115906 cites W2028673251 @default.
- W3159115906 cites W2036897871 @default.
- W3159115906 cites W2037199116 @default.
- W3159115906 cites W2040151959 @default.
- W3159115906 cites W2040454760 @default.
- W3159115906 cites W2052388444 @default.
- W3159115906 cites W2067656626 @default.
- W3159115906 cites W2069086990 @default.
- W3159115906 cites W2073109785 @default.
- W3159115906 cites W2074006690 @default.
- W3159115906 cites W2074677800 @default.
- W3159115906 cites W2078845104 @default.
- W3159115906 cites W2079096821 @default.
- W3159115906 cites W2079563665 @default.
- W3159115906 cites W2080169144 @default.
- W3159115906 cites W2081127271 @default.
- W3159115906 cites W2084856835 @default.
- W3159115906 cites W2107398329 @default.
- W3159115906 cites W2114104545 @default.
- W3159115906 cites W2115517051 @default.
- W3159115906 cites W2121793799 @default.
- W3159115906 cites W2122730216 @default.
- W3159115906 cites W2129702476 @default.
- W3159115906 cites W2131856634 @default.
- W3159115906 cites W2134118606 @default.
- W3159115906 cites W2138207763 @default.
- W3159115906 cites W2147734635 @default.
- W3159115906 cites W2148043260 @default.
- W3159115906 cites W2148700080 @default.
- W3159115906 cites W2148831483 @default.
- W3159115906 cites W2169456326 @default.
- W3159115906 cites W2178318681 @default.
- W3159115906 cites W2179454156 @default.
- W3159115906 cites W2198353771 @default.
- W3159115906 cites W2220553089 @default.
- W3159115906 cites W2307154186 @default.
- W3159115906 cites W2339828620 @default.
- W3159115906 cites W2351547314 @default.
- W3159115906 cites W2395887422 @default.
- W3159115906 cites W2507670193 @default.
- W3159115906 cites W2529263647 @default.
- W3159115906 cites W2552168394 @default.
- W3159115906 cites W2553214673 @default.
- W3159115906 cites W2562256628 @default.
- W3159115906 cites W2588627862 @default.
- W3159115906 cites W2747290830 @default.
- W3159115906 cites W2752414510 @default.
- W3159115906 cites W2767546566 @default.
- W3159115906 cites W2772122018 @default.
- W3159115906 cites W2782013549 @default.
- W3159115906 cites W2794686680 @default.
- W3159115906 cites W2807667713 @default.
- W3159115906 cites W2889307054 @default.
- W3159115906 cites W2896648752 @default.
- W3159115906 cites W2899044125 @default.
- W3159115906 cites W2902050434 @default.
- W3159115906 cites W2902652978 @default.
- W3159115906 cites W2906889822 @default.