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• W3159143437 abstract "Long interspersed element-1 (LINE-1, L1) retrotransposon composes about 17% of the human genome. However, genetic and biochemical interactions between L1 and hepatitis B virus (HBV) remain poorly understood. In this study, we found that HBV restricts L1 mobility without inhibiting the L1 promoter activity. Notably, HBV polymerase (Pol) strongly inhibited L1 retrotransposition in a reverse transcriptase (RT)-independent manner. Indeed, the ribonuclease H (RNase H) domain was essential for inhibition of L1 retrotransposition. L1 ORF1p RNA-binding protein predominantly localized into cytoplasmic RNA granule termed P-body. However, HBV Pol sequestered L1 ORF1p from P-body and colocalized with L1 ORF1p in cytoplasm, when both proteins were co-expressed. Altogether, HBV Pol seems to restrict L1 mobility through a sequestration of L1 ORF1p from P-body. Thus, these results suggest a novel function or activity of HBV Pol in regulation of L1 retrotransposition." @default.
• W3159143437 created "2021-05-10" @default.
• W3159143437 creator A5025644300 @default.
• W3159143437 date "2021-05-07" @default.
• W3159143437 modified "2023-09-23" @default.
• W3159143437 title "Hepatitis B virus polymerase restricts LINE-1 retrotransposition" @default.
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• W3159143437 doi "https://doi.org/10.1101/2021.05.07.443105" @default.
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