Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159164211> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3159164211 abstract "The apoptosis of proximal tubule epithelial cells (PTECs) is a critical event of acute kidney injury (AKI). Tetratricopeptide repeat domain 36 (TTC36) with three tetratricopeptide repeats is evolutionarily conserved across mammals, which functions as a chaperone for heat shock protein 70. We have revealed that TTC36 is specifically expressed in PTECs in our previous work. There are few studies about the role TTC36 played in AKI. Therefore, in this study, we investigated the function of TTC36 in the apoptosis of HK2 cells, which are derived from the human proximal tubule. Firstly, we observed that TTC36 was obviously down-regulated and was negatively related to the kidney damage degree in a mouse model of acute kidney injury established by ischemia/reperfusion. Besides, TTC36 overexpression protected HK2 cells against cisplatin-induced apoptosis. Moreover, we discovered the mechanism that TTC36 mitigated cisplatin-triggered mitochondrial disorder via sustaining the membrane potential of mitochondria and mitochondrial autophagy-related gene expression. Collectively, these results suggested that TTC36 plays a protective role in the cisplatin-induced apoptosis of renal tubular cells through maintaining the mitochondrial potential and mitochondrial autophagy-related gene expression. These observations highlight the essential role of TTC36 in regulating PTEC apoptosis and imply TTC36/mitochondrial homeostasis axis as a potential target for the therapeutic intervention in AKI." @default.
- W3159164211 created "2021-05-10" @default.
- W3159164211 creator A5000350295 @default.
- W3159164211 creator A5001729142 @default.
- W3159164211 creator A5008582313 @default.
- W3159164211 creator A5040985281 @default.
- W3159164211 creator A5054596313 @default.
- W3159164211 creator A5055776001 @default.
- W3159164211 creator A5081065929 @default.
- W3159164211 date "2021-04-26" @default.
- W3159164211 modified "2023-09-27" @default.
- W3159164211 title "Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis" @default.
- W3159164211 cites W2013614229 @default.
- W3159164211 cites W2140224923 @default.
- W3159164211 cites W2172127581 @default.
- W3159164211 cites W2178356336 @default.
- W3159164211 cites W2264921308 @default.
- W3159164211 cites W2547402558 @default.
- W3159164211 cites W2581248702 @default.
- W3159164211 cites W2604619953 @default.
- W3159164211 cites W2743743758 @default.
- W3159164211 cites W2750514629 @default.
- W3159164211 cites W2911118120 @default.
- W3159164211 cites W2928105237 @default.
- W3159164211 cites W2944155224 @default.
- W3159164211 cites W2944370458 @default.
- W3159164211 cites W2973555580 @default.
- W3159164211 cites W3048150372 @default.
- W3159164211 cites W3091775488 @default.
- W3159164211 doi "https://doi.org/10.1101/2021.04.25.441359" @default.
- W3159164211 hasPublicationYear "2021" @default.
- W3159164211 type Work @default.
- W3159164211 sameAs 3159164211 @default.
- W3159164211 citedByCount "0" @default.
- W3159164211 crossrefType "posted-content" @default.
- W3159164211 hasAuthorship W3159164211A5000350295 @default.
- W3159164211 hasAuthorship W3159164211A5001729142 @default.
- W3159164211 hasAuthorship W3159164211A5008582313 @default.
- W3159164211 hasAuthorship W3159164211A5040985281 @default.
- W3159164211 hasAuthorship W3159164211A5054596313 @default.
- W3159164211 hasAuthorship W3159164211A5055776001 @default.
- W3159164211 hasAuthorship W3159164211A5081065929 @default.
- W3159164211 hasBestOaLocation W31591642111 @default.
- W3159164211 hasConcept C104317684 @default.
- W3159164211 hasConcept C126322002 @default.
- W3159164211 hasConcept C185592680 @default.
- W3159164211 hasConcept C188018408 @default.
- W3159164211 hasConcept C190283241 @default.
- W3159164211 hasConcept C203522944 @default.
- W3159164211 hasConcept C2776694085 @default.
- W3159164211 hasConcept C2778239845 @default.
- W3159164211 hasConcept C2780091579 @default.
- W3159164211 hasConcept C2780472472 @default.
- W3159164211 hasConcept C28859421 @default.
- W3159164211 hasConcept C502942594 @default.
- W3159164211 hasConcept C54355233 @default.
- W3159164211 hasConcept C55493867 @default.
- W3159164211 hasConcept C63645605 @default.
- W3159164211 hasConcept C71924100 @default.
- W3159164211 hasConcept C86803240 @default.
- W3159164211 hasConcept C95444343 @default.
- W3159164211 hasConceptScore W3159164211C104317684 @default.
- W3159164211 hasConceptScore W3159164211C126322002 @default.
- W3159164211 hasConceptScore W3159164211C185592680 @default.
- W3159164211 hasConceptScore W3159164211C188018408 @default.
- W3159164211 hasConceptScore W3159164211C190283241 @default.
- W3159164211 hasConceptScore W3159164211C203522944 @default.
- W3159164211 hasConceptScore W3159164211C2776694085 @default.
- W3159164211 hasConceptScore W3159164211C2778239845 @default.
- W3159164211 hasConceptScore W3159164211C2780091579 @default.
- W3159164211 hasConceptScore W3159164211C2780472472 @default.
- W3159164211 hasConceptScore W3159164211C28859421 @default.
- W3159164211 hasConceptScore W3159164211C502942594 @default.
- W3159164211 hasConceptScore W3159164211C54355233 @default.
- W3159164211 hasConceptScore W3159164211C55493867 @default.
- W3159164211 hasConceptScore W3159164211C63645605 @default.
- W3159164211 hasConceptScore W3159164211C71924100 @default.
- W3159164211 hasConceptScore W3159164211C86803240 @default.
- W3159164211 hasConceptScore W3159164211C95444343 @default.
- W3159164211 hasLocation W31591642111 @default.
- W3159164211 hasOpenAccess W3159164211 @default.
- W3159164211 hasPrimaryLocation W31591642111 @default.
- W3159164211 hasRelatedWork W10786378 @default.
- W3159164211 hasRelatedWork W1080437 @default.
- W3159164211 hasRelatedWork W11924396 @default.
- W3159164211 hasRelatedWork W12709579 @default.
- W3159164211 hasRelatedWork W14343437 @default.
- W3159164211 hasRelatedWork W18792685 @default.
- W3159164211 hasRelatedWork W2155711 @default.
- W3159164211 hasRelatedWork W21570698 @default.
- W3159164211 hasRelatedWork W8866098 @default.
- W3159164211 hasRelatedWork W930746 @default.
- W3159164211 isParatext "false" @default.
- W3159164211 isRetracted "false" @default.
- W3159164211 magId "3159164211" @default.
- W3159164211 workType "article" @default.