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- W3159194151 abstract "<b>Background:</b> Obstructive sleep apnea (OSA) and diabetes type 2 are high prevalent diseases with major public health impact, sharing a complex relationship. <b>Aims and Objectives:</b> Τo evaluate the influence of OSA severity on prevalent diabetes in a large clinical population of patients. <b>Methods:</b> We identified a sample of 2,279 patients (mean age 55 years, 74% men) who undergone a diagnostic polysomnography and completed the Epworth sleepiness scale (ESS). We investigated the prevalence of diabetes type 2 in patients with newly diagnosed OSA and analyzed the risk of severe OSA for prevalent diabetes after adjustment for relevant confounding factors including gender, age, smoking, obesity, daytime sleepiness and comorbidities. <b>Results:</b> The prevalence of Diabetes in OSA patients was 19.8%, which was 4.4 times higher than that in patients without OSA (4.5%). Diabetes was more prevalent in severe (26%) and moderate (12%) OSA compared to mild OSA (5%, p<0.001 among all). Following multivariable adjustment, severe OSA remained a significant predictor for diabetes [odds ratio (95% CI) 2.922 (1.346–6343), p=0.007]. Further analysis demonstrated[s1] that severe OSA predicted prevalent diabetes mainly in younger (<60 years) [OR (95% CI) 5.246 (1.523–18.070), p=0.009] and sleepy (ESS≥10) patients [OR (95% CI) 5.726 (1.298–25.264), p=0.021]. <b>Conclusion:</b> Our results showed that severe OSA associated with an independent 3-time risk increase for type 2 diabetes in this large clinical patient cohort. These data suggest that there is value in systematic screening for diabetes in severe OSA patients, especially in younger and sleepy patients." @default.
- W3159194151 created "2021-05-10" @default.
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- W3159194151 date "2021-04-16" @default.
- W3159194151 modified "2023-09-27" @default.
- W3159194151 title "The impact of obstructive sleep apnea (OSA) severity on type 2 diabetes prevalence" @default.
- W3159194151 doi "https://doi.org/10.1183/23120541.sleepandbreathing-2021.67" @default.
- W3159194151 hasPublicationYear "2021" @default.
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