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• W3159217090 abstract "Abstract Multi-scanner MRI studies are reliant on understanding the apparent differences in imaging measures between different scanners. We provide a comprehensive analysis of T1-weighted and diffusion MRI (dMRI) structural brain measures between a 1.5T GE Signa Horizon HDx and a 3T Siemens Magnetom Prisma using 91 community-dwelling older participants (aged 82 years). Although we found considerable differences in absolute measurements (global tissue volumes were measured as ∼6—11% higher and fractional anisotropy was 33% higher at 3T than at 1.5T), between-scanner consistency was good to excellent for global volumetric and dMRI measures (intraclass correlation coefficient [ICC] range: 0.612—0.993) and fair to good for 68 cortical regions (FreeSurfer) and cortical surface measures (mean ICC: 0.504—0.763). Between-scanner consistency was fair for dMRI measures of 12 major white matter tracts (mean ICC: 0.475—0.564), and the general factors of these tracts provided excellent consistency (ICC ≥ 0.769). Whole-brain structural networks provided good to excellent consistency for global metrics (ICC ≥ 0.612). Although consistency was poor for individual network connections (mean ICCs: 0.275 – 0.280), this was driven by a large difference in network sparsity (0.599 versus 0.334), and consistency was improved when comparing only the connections present in every participant (mean ICCs: 0.533—0.647). Regression-based k-fold cross-validation showed that, particularly for global volumes, between-scanner differences could be largely eliminated (R 2 range 0.615—0.991). We conclude that low granularity measures of brain structure can be reliably matched between the scanners tested, but caution is warranted when combining high granularity information from different scanners." @default.
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• W3159217090 date "2021-04-26" @default.
• W3159217090 modified "2023-09-25" @default.
• W3159217090 title "Comparison of structural MRI brain measures between 1.5T and 3T: data from the Lothian Birth Cohort 1936" @default.
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• W3159217090 doi "https://doi.org/10.1101/2021.04.23.21256000" @default.
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