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- W3159227451 abstract "Despite the impressive efficacies demonstrated in preclinical research, hundreds of potentially neuroprotective drugs have failed to provide effective neuroprotection for ischemic stroke in human clinical trials. Lack of a powerful animal model for human ischemic stroke could be a major reason for the failure to develop successful neuroprotective drugs for ischemic stroke. This review recapitulates the available cerebral ischemia animal models, provides an anatomical comparison of the circle of Willis of each species, and describes the functional assessment tests used in these ischemic stroke models. The distinct differences between human ischemic stroke and experimental stroke in available animal models is explored. Innovative animal models more closely resembling human strokes, better techniques in functional outcome assessment and better experimental designs generating clearer and stronger evidence may help realise the development of truly neuroprotective drugs that will benefit human ischemic stroke patients. This may involve use of newer molecules or revisiting earlier studies with new experimental designs. Translation of any resultant successes may then be tested in human clinical trials with greater confidence and optimism." @default.
- W3159227451 created "2021-05-10" @default.
- W3159227451 creator A5013571707 @default.
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- W3159227451 creator A5029763334 @default.
- W3159227451 creator A5045703323 @default.
- W3159227451 creator A5068530072 @default.
- W3159227451 date "2021-04-23" @default.
- W3159227451 modified "2023-10-09" @default.
- W3159227451 title "Preclinical animal studies in ischemic stroke: Challenges and some solutions" @default.
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