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• W3159281508 endingPage "2026" @default.
• W3159281508 startingPage "2019" @default.
• W3159281508 abstract "Human papillomavirus (HPV) infection is a risk factor for penile cancer (PC). The miR-145 expression has been correlated to this virus genomic amplification. In this context, this work aims to determine the expression level of miR-145 in penile tumors infected by high-risk HPV and correlate it with the clinicopathological characteristics of the tumor and protein expression of p53.Formalin-fixed paraffin-embedded from 52 patients with PC, at diagnosis and prior to any cancer treatment, were obtained. HPV identification was performed by nested type PCR, and miR-145 expression was obtained by qRT-PCR. Immunohistochemical analysis of p53 and Ki-67 was performed.Tumoral miR-145 expression was significantly lower compared to adjacent tissue. Additionally, there was a significant reduction of miR-145 expression in invasion perineural, histological associated HPV, and absence of p53 expression in positive HPV cases. HPV infection was detected in 86.5%, the most frequent HPV16. Reduced disease-free survival was observed in patients with low expression of miR-145.Our data suggest that the underexpression of miR-145 may be triggered by HPV action, decreasing protein expression of p53, and being correlated with perineural invasion. Therefore, the deregulation of miR-145 provides clues as to the potential role in penile carcinogenesis and is also a potential candidate for validation in noninvasive samples." @default.
• W3159281508 created "2021-05-10" @default.
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• W3159281508 date "2021-05-01" @default.
• W3159281508 modified "2023-09-27" @default.
• W3159281508 title "Downregulation of miR-145 is associated with perineural invasion in penile carcinoma" @default.
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• W3159281508 doi "https://doi.org/10.21037/tau-20-1378" @default.
• W3159281508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8185688" @default.
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