FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159288742> ?p ?o ?g. }

• W3159288742 endingPage "486" @default.
• W3159288742 startingPage "480" @default.
• W3159288742 abstract "Calcium-activated chloride channel 2 (CLCA2) is closely related to the invasion, metastasis, and prognosis of some common malignant tumors. The present study aimed to evaluate the role of CLCA2 in cervical squamous cell carcinoma (CESC) using bioinformatics analysis. The mRNA sequencing data and the corresponding clinical data were obtained from Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database respectively. Then univariate analysis of variance was used to analyze the differential mRNA expression of CLCA2 between normal, cervical Intraepithelial neoplasia (CIN), and CESC tissues and clinicopathological characteristics. The Gene Expression Profiling Interactive Analysis (GEPIA) was used to assess the association between CLCA2 and Disease-Free Survival (DFS), overall survival (OS). The Gene Set Enrichment Analysis (GSEA) was used to explore the associated signaling pathways. The Tumor Immune Estimation Resource (TIMER) was used to predict the potential biological roles of CLCA2 in tumor-immune of CESC. CLCA2 expression was significantly decreased in CESC tissues compared with normal and CIN tissues (P < 0.05). Meanwhile, obese patients had lower levels of CLCA2 expression than normal-weight CESC patients (P < 0.05). However, there was no significant difference in the expression level of CLCA2 in patients with different T stage, lymph node status, metastasis, and FIGO stage in CC(P > 0.05). The survival analysis indicated that for DFS, CESC with high CLCA2 expression was associated with better prognoses compared with those with low expression levels (P < 0.05). But for the OS, there was no difference. GSEA revealed that 4 pathways exhibited significant differential enrichment in the CLCA2 high-expression phenotype, including the P53 signaling pathway, the ERBB signaling pathway, the NOTCH signaling pathway, and the ubiquitin-mediated proteolysis. The TIMER reveals the expression of CLCA2 showed a significant inverse association with the number of B cells, Macrophage cells, and Dendritic Cell infiltration. The present study indicates that CLCA2 expression may be a potential prognostic marker for patients with CESC." @default.
• W3159288742 created "2021-05-10" @default.
• W3159288742 creator A5002661071 @default.
• W3159288742 creator A5019018136 @default.
• W3159288742 creator A5027640347 @default.
• W3159288742 creator A5029120663 @default.
• W3159288742 creator A5032560526 @default.
• W3159288742 creator A5086258574 @default.
• W3159288742 date "2021-05-01" @default.
• W3159288742 modified "2023-10-16" @default.
• W3159288742 title "Decreased expression of CLCA2 and the correlating with immune infiltrates in patients with cervical squamous cell carcinoma: A bioinformatics analysis" @default.
• W3159288742 cites W1576040396 @default.
• W3159288742 cites W1638688995 @default.
• W3159288742 cites W1978794235 @default.
• W3159288742 cites W1991220959 @default.
• W3159288742 cites W1997608717 @default.
• W3159288742 cites W2023640026 @default.
• W3159288742 cites W2033715459 @default.
• W3159288742 cites W2083912864 @default.
• W3159288742 cites W2100761652 @default.
• W3159288742 cites W2115804548 @default.
• W3159288742 cites W2204583106 @default.
• W3159288742 cites W2321127785 @default.
• W3159288742 cites W2346651667 @default.
• W3159288742 cites W2465413281 @default.
• W3159288742 cites W2548000951 @default.
• W3159288742 cites W2576240842 @default.
• W3159288742 cites W2620509177 @default.
• W3159288742 cites W2775731014 @default.
• W3159288742 cites W2793298349 @default.
• W3159288742 cites W2809927600 @default.
• W3159288742 cites W2889646458 @default.
• W3159288742 cites W2891030524 @default.
• W3159288742 cites W2899871244 @default.
• W3159288742 cites W2981250531 @default.
• W3159288742 cites W2998988837 @default.
• W3159288742 doi "https://doi.org/10.1016/j.tjog.2021.03.016" @default.
• W3159288742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33966732" @default.
• W3159288742 hasPublicationYear "2021" @default.
• W3159288742 type Work @default.
• W3159288742 sameAs 3159288742 @default.
• W3159288742 citedByCount "3" @default.
• W3159288742 countsByYear W31592887422022 @default.
• W3159288742 countsByYear W31592887422023 @default.
• W3159288742 crossrefType "journal-article" @default.
• W3159288742 hasAuthorship W3159288742A5002661071 @default.
• W3159288742 hasAuthorship W3159288742A5019018136 @default.
• W3159288742 hasAuthorship W3159288742A5027640347 @default.
• W3159288742 hasAuthorship W3159288742A5029120663 @default.
• W3159288742 hasAuthorship W3159288742A5032560526 @default.
• W3159288742 hasAuthorship W3159288742A5086258574 @default.
• W3159288742 hasBestOaLocation W31592887421 @default.
• W3159288742 hasConcept C121608353 @default.
• W3159288742 hasConcept C126322002 @default.
• W3159288742 hasConcept C143998085 @default.
• W3159288742 hasConcept C144301174 @default.
• W3159288742 hasConcept C203014093 @default.
• W3159288742 hasConcept C2777343196 @default.
• W3159288742 hasConcept C2778220009 @default.
• W3159288742 hasConcept C2779013556 @default.
• W3159288742 hasConcept C38180746 @default.
• W3159288742 hasConcept C502942594 @default.
• W3159288742 hasConcept C71924100 @default.
• W3159288742 hasConcept C8891405 @default.
• W3159288742 hasConceptScore W3159288742C121608353 @default.
• W3159288742 hasConceptScore W3159288742C126322002 @default.
• W3159288742 hasConceptScore W3159288742C143998085 @default.
• W3159288742 hasConceptScore W3159288742C144301174 @default.
• W3159288742 hasConceptScore W3159288742C203014093 @default.
• W3159288742 hasConceptScore W3159288742C2777343196 @default.
• W3159288742 hasConceptScore W3159288742C2778220009 @default.
• W3159288742 hasConceptScore W3159288742C2779013556 @default.
• W3159288742 hasConceptScore W3159288742C38180746 @default.
• W3159288742 hasConceptScore W3159288742C502942594 @default.
• W3159288742 hasConceptScore W3159288742C71924100 @default.
• W3159288742 hasConceptScore W3159288742C8891405 @default.
• W3159288742 hasFunder F4320321001 @default.
• W3159288742 hasIssue "3" @default.
• W3159288742 hasLocation W31592887421 @default.
• W3159288742 hasLocation W31592887422 @default.
• W3159288742 hasLocation W31592887423 @default.
• W3159288742 hasOpenAccess W3159288742 @default.
• W3159288742 hasPrimaryLocation W31592887421 @default.
• W3159288742 hasRelatedWork W1499339123 @default.
• W3159288742 hasRelatedWork W1975859778 @default.
• W3159288742 hasRelatedWork W2154708791 @default.
• W3159288742 hasRelatedWork W2404360950 @default.
• W3159288742 hasRelatedWork W2415240724 @default.
• W3159288742 hasRelatedWork W2763237291 @default.
• W3159288742 hasRelatedWork W3173207637 @default.
• W3159288742 hasRelatedWork W4283771460 @default.
• W3159288742 hasRelatedWork W4304116770 @default.
• W3159288742 hasRelatedWork W4361261034 @default.
• W3159288742 hasVolume "60" @default.
• W3159288742 isParatext "false" @default.
• W3159288742 isRetracted "false" @default.
• W3159288742 magId "3159288742" @default.
• W3159288742 workType "article" @default.