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- W3159296937 abstract "• Highly-ordered enzyme-free localized DNA cascade reaction (HELDCR) was designed. • The MBs were used to achieve the high loading of DNA for HELDCR. • The MBs-assisted HELDCR reduced the reaction time and enhanced the hybridization efficiency. • The integration of HELDCR and target recycling achieved the sensitive detection of Pb 2+ . The localized hairpin-DNA cascade reaction exhibited some fascinating merits over the traditional hairpin-DNA hybridization reaction, such as the reduced reaction time and enhanced hybridization efficiency. However, the reported localized hairpin-DNA cascade reaction usually needed the participation of expensive proteases, which limited their application. This work developed a magnetic nanobeads (MBs)-assisted highly-ordered enzyme-free localized DNA cascade reaction (HELDCR) to achieve highly efficient signal amplification. With the help of magnetically separable MBs, a novel fluorescent sensor was constructed for the ultrasensitive detection of Pb 2+ . In the presence of the target Pb 2+ , the DNAzyme chain was activated and the substrate chain was cleaved. The released DNAzyme chain could trigger the HELDCR and open the highly-ordered assembled hairpin structures (HAHs) on MBs, which promoted substantial fluorophores FAM and quenchers BHQ mutually close. The proximity of FAM and BHQ caused signal quenching, thus achieving a satisfactory performance for detecting Pb 2+ with a low detection limit of 3.0 pM. The synergistic effect of the HELDCR and MBs provided an attractive and sensitive fluorescent platform for biological analysis in the homogeneous environment." @default.
- W3159296937 created "2021-05-10" @default.
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- W3159296937 date "2021-09-01" @default.
- W3159296937 modified "2023-10-18" @default.
- W3159296937 title "A novel magnetic beads-assisted highly-ordered enzyme-free localized DNA cascade reaction for the fluorescence detection of Pb2+" @default.
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- W3159296937 doi "https://doi.org/10.1016/j.snb.2021.130040" @default.
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