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• W3159299963 abstract "Abstract Sperm aging is accelerated by the buildup of reactive oxygen species (ROS), which cause oxidative damage to various cellular components. Aging can be slowed by limiting the production of mitochondrial ROS and by increasing the production of antioxidants, both of which can be generated in the sperm cell itself or in the surrounding somatic tissues of the male and female reproductive tracts. However, few studies have compared the separate contributions of ROS production and ROS scavenging to sperm aging, or to cellular aging in general. We measured reproductive fitness in two lines of Drosophila melanogaster genetically engineered to (1) produce fewer ROS via expression of alternative oxidase (AOX), an alternative respiratory pathway; or (2) scavenge fewer ROS due to a loss-of-function mutation in the antioxidant gene dj-1 β. Wild-type females mated to AOX males had increased fecundity and longer fertility durations, consistent with slower aging in AOX sperm. Contrary to expectations, fitness was not reduced in wild-type females mated to dj-1 β males. Fecundity and fertility duration were increased in AOX and decreased in dj-1 β females, indicating that female ROS levels may affect aging rates in stored sperm and/or eggs. Finally, we found evidence that accelerated aging in dj-1 β sperm may have selected for more frequent mating. Our results help to clarify the relative roles of ROS production and ROS scavenging in the male and female reproductive systems." @default.
• W3159299963 created "2021-05-10" @default.
• W3159299963 creator A5004639010 @default.
• W3159299963 creator A5045220778 @default.
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• W3159299963 date "2021-04-26" @default.
• W3159299963 modified "2023-09-26" @default.
• W3159299963 title "Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster" @default.
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• W3159299963 doi "https://doi.org/10.1007/s10522-021-09922-1" @default.
• W3159299963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8266701" @default.
• W3159299963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33903991" @default.
• W3159299963 hasPublicationYear "2021" @default.
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