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• W3159301223 abstract "Abstract The dorsolateral bed nucleus of the stria terminalis (BNST DL ) has high expression of oxytocin (OT) receptors (OTR), which were shown to facilitate cued fear. However, the role of OTR in the modulation of BNST DL activity remains elusive. BNST DL contains GABA-ergic neurons classified based on intrinsic membrane properties into three types. Using in vitro patch-clamp recordings in male rats, we demonstrate that OT selectively excites and increases spontaneous firing rate of Type I BNST DL neurons. As a consequence, OT increases the frequency, but not amplitude, of spontaneous inhibitory post-synaptic currents (sIPSCs) selectively in Type II neurons, an effect abolished by OTR antagonist or tetrodotoxin, and reduces spontaneous firing rate in these neurons. These results suggest an indirect effect of OT in Type II neurons, which is mediated via OT-induced increase in firing of Type I interneurons. As Type II BNST DL neurons were shown projecting to the central amygdala (CeA), we also recorded from retrogradelly labeled BNST→CeA neurons and we show that OT increases the frequency of sIPSC in these Type II BNST→CeA output neurons. In contrast, in Type III neurons, OT reduces the amplitude, but not frequency, of both sIPSCs and evoked IPSCs via a postsynaptic mechanism without changing their intrinsic excitability. We present a model of fine-tuned modulation of BNST DL activity by OT, which selectively excites BNST DL interneurons and inhibits Type II BNST→CeA output neurons. These results suggest that OTR in the BNST might facilitate cued fear by inhibiting the BNST→CeA neurons. Highlights Oxytocin directly excites and increases spontaneous firing of Type I BNST interneurons Oxytocin indirectly inhibits Type II BNST neurons Oxytocin inhibits Type II BNST output neurons to the central amygdala (BNST→CeA) Oxytocin reduces GABA-ergic transmission in Type III BNST neurons Oxytocin might facilitate cued fear by inhibiting the Type II BNST→CeA neurons Graphical abstract" @default.
• W3159301223 created "2021-05-10" @default.
• W3159301223 creator A5012923877 @default.
• W3159301223 creator A5025811064 @default.
• W3159301223 creator A5032796984 @default.
• W3159301223 creator A5059422595 @default.
• W3159301223 date "2020-06-25" @default.
• W3159301223 modified "2023-10-04" @default.
• W3159301223 title "Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala" @default.
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• W3159301223 doi "https://doi.org/10.1101/2020.06.24.169466" @default.
• W3159301223 hasPublicationYear "2020" @default.
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