FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159329523> ?p ?o ?g. }

• W3159329523 endingPage "2617" @default.
• W3159329523 startingPage "2607" @default.
• W3159329523 abstract "An analytical strategy for a matrix-assisted laser desorption mass spectrometry-based untargeted metabolomic study on vitreous humor (VH) was developed, looking for statistically significant parameters correlated to death time estimation. Five incubation stages of VH, 0, 24, 48, 72, and 96 h, at physiological pH and controlled temperature, were adopted to monitor time-dependent changes and correlate them with the postmortem interval (PMI). Using two multivariate statistical approaches, principal component regression (PCR) and partial least squares regression (PLSR), the PMI was assessed, considering the m/z values from mass spectra and the incubation time (ISt) as predictors. An independent validation set was used to evaluate the predictive capability of the models through the coefficient of determination (R2) and the root-mean-square error (RMSE). Different pre-treatments were applied to the raw mass spectra, and their performance in assessing PMI was evaluated. Based on the best outcomes in terms of both R2 and RMSE, multiplicative scatter correction combined with a logarithmic transformation was chosen. The results of PCR and PLSR based on the selected pre-treatment are encouraging because validation R2 is about 0.95 for both models. Moreover, the prediction error is 6 h for both models, when PMI is lower than 1 day. Although these results are obtained by the uncritical application of the models, they are comparable to or even better than those reported in the literature. Notwithstanding, we consider that many in situ influences, such as passive diffusion, functional loss of tissues, and advanced autolytic processes, could not get captured in vitro. However, the developed approach was optimized using VH samples and overcomes the limitations of the vast majority of methods that require validation for serum and/or urine samples." @default.
• W3159329523 created "2021-05-10" @default.
• W3159329523 creator A5021055428 @default.
• W3159329523 creator A5023926110 @default.
• W3159329523 creator A5045151309 @default.
• W3159329523 creator A5045590306 @default.
• W3159329523 creator A5056198822 @default.
• W3159329523 creator A5082015832 @default.
• W3159329523 creator A5089245215 @default.
• W3159329523 date "2021-04-27" @default.
• W3159329523 modified "2023-10-16" @default.
• W3159329523 title "Analytical Strategy for MS-Based Thanatochemistry to Estimate Postmortem Interval" @default.
• W3159329523 cites W1496694786 @default.
• W3159329523 cites W1946861950 @default.
• W3159329523 cites W1963651888 @default.
• W3159329523 cites W1983861137 @default.
• W3159329523 cites W2005409139 @default.
• W3159329523 cites W2016090370 @default.
• W3159329523 cites W2023805848 @default.
• W3159329523 cites W2028145110 @default.
• W3159329523 cites W2045125597 @default.
• W3159329523 cites W2048225803 @default.
• W3159329523 cites W2054715966 @default.
• W3159329523 cites W2060379650 @default.
• W3159329523 cites W2063417654 @default.
• W3159329523 cites W2065494599 @default.
• W3159329523 cites W2067664488 @default.
• W3159329523 cites W2075689706 @default.
• W3159329523 cites W2075787088 @default.
• W3159329523 cites W2082821545 @default.
• W3159329523 cites W2082993539 @default.
• W3159329523 cites W2088610467 @default.
• W3159329523 cites W2109606373 @default.
• W3159329523 cites W2122692805 @default.
• W3159329523 cites W2124347152 @default.
• W3159329523 cites W2126544695 @default.
• W3159329523 cites W2139257863 @default.
• W3159329523 cites W2152822358 @default.
• W3159329523 cites W2158863190 @default.
• W3159329523 cites W2164518567 @default.
• W3159329523 cites W2166021020 @default.
• W3159329523 cites W2219052569 @default.
• W3159329523 cites W2301389244 @default.
• W3159329523 cites W2314779030 @default.
• W3159329523 cites W2345049124 @default.
• W3159329523 cites W2422137723 @default.
• W3159329523 cites W2556587018 @default.
• W3159329523 cites W2577949882 @default.
• W3159329523 cites W2593812273 @default.
• W3159329523 cites W2754447899 @default.
• W3159329523 cites W2883830857 @default.
• W3159329523 cites W2897435302 @default.
• W3159329523 cites W2932145904 @default.
• W3159329523 cites W2943849175 @default.
• W3159329523 cites W2969664314 @default.
• W3159329523 cites W2978262530 @default.
• W3159329523 cites W2996219946 @default.
• W3159329523 cites W3012426287 @default.
• W3159329523 cites W3024799945 @default.
• W3159329523 cites W46740975 @default.
• W3159329523 doi "https://doi.org/10.1021/acs.jproteome.0c01038" @default.
• W3159329523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33905255" @default.
• W3159329523 hasPublicationYear "2021" @default.
• W3159329523 type Work @default.
• W3159329523 sameAs 3159329523 @default.
• W3159329523 citedByCount "7" @default.
• W3159329523 countsByYear W31593295232022 @default.
• W3159329523 countsByYear W31593295232023 @default.
• W3159329523 crossrefType "journal-article" @default.
• W3159329523 hasAuthorship W3159329523A5021055428 @default.
• W3159329523 hasAuthorship W3159329523A5023926110 @default.
• W3159329523 hasAuthorship W3159329523A5045151309 @default.
• W3159329523 hasAuthorship W3159329523A5045590306 @default.
• W3159329523 hasAuthorship W3159329523A5056198822 @default.
• W3159329523 hasAuthorship W3159329523A5082015832 @default.
• W3159329523 hasAuthorship W3159329523A5089245215 @default.
• W3159329523 hasConcept C105795698 @default.
• W3159329523 hasConcept C113196181 @default.
• W3159329523 hasConcept C134306372 @default.
• W3159329523 hasConcept C139945424 @default.
• W3159329523 hasConcept C152877465 @default.
• W3159329523 hasConcept C161584116 @default.
• W3159329523 hasConcept C185592680 @default.
• W3159329523 hasConcept C22354355 @default.
• W3159329523 hasConcept C27438332 @default.
• W3159329523 hasConcept C33923547 @default.
• W3159329523 hasConcept C39927690 @default.
• W3159329523 hasConcept C42747912 @default.
• W3159329523 hasConcept C43617362 @default.
• W3159329523 hasConcept C48921125 @default.
• W3159329523 hasConcept C74887250 @default.
• W3159329523 hasConceptScore W3159329523C105795698 @default.
• W3159329523 hasConceptScore W3159329523C113196181 @default.
• W3159329523 hasConceptScore W3159329523C134306372 @default.
• W3159329523 hasConceptScore W3159329523C139945424 @default.
• W3159329523 hasConceptScore W3159329523C152877465 @default.
• W3159329523 hasConceptScore W3159329523C161584116 @default.
• W3159329523 hasConceptScore W3159329523C185592680 @default.

• next