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• W3159332478 abstract "Abstract NmMetQ is a substrate binding protein (SBP) from Neisseria meningitidis that has been identified as a surface-exposed candidate antigen for meningococcal vaccines. However, this location for NmMetQ challenges the prevailing view that SBPs in Gram-negative bacteria are localized to the periplasmic space to promote interaction with their cognate ABC transporter embedded in the bacterial inner membrane. To address the roles of NmMetQ, we characterized NmMetQ with and without its cognate ABC transporter (NmMetNI). Here, we show that NmMetQ is a lipoprotein (lipo-NmMetQ) that binds multiple methionine analogs and stimulates the ATPase activity of NmMetNI. Using single-particle electron cryo-microscopy, we determined the structures of NmMetNI in the absence and presence of lipo-NmMetQ. Based on our data, we propose that NmMetQ tethers to membranes via a lipid anchor and has dual function/topology, playing a role in NmMetNI-mediated transport at the inner-membrane in addition to moonlighting functions on the bacterial surface." @default.
• W3159332478 created "2021-05-10" @default.
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• W3159332478 date "2021-05-04" @default.
• W3159332478 modified "2023-09-26" @default.
• W3159332478 title "Characterization of the ABC methionine transporter from Neisseria meningitidis reveals that MetQ is a lipoprotein" @default.
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• W3159332478 doi "https://doi.org/10.1101/2021.05.04.442564" @default.
• W3159332478 hasPublicationYear "2021" @default.
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