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- W3159351663 abstract "Isoflucypram belongs to the new generation of succinate dehydrogenase inhibitor (SDHI) fungicides that are commonly used in crop fungal disease control. Evidence indicates that isoflucypram poses a potential risk to aquatic organisms. However, the effects of isoflucypram during early embryogenesis are not fully understood. In the present study, zebrafish embryos were exposed to 0.025, 0.25, or 2.5 μM isoflucypram for three days. Isoflucypram caused severe developmental abnormalities (yolk sac edema, pericardial edema, and blood clotting clustering), hatching delay, and decreased heart rates in zebrafish. The expression levels of cardiac-specific genes (nkx2.5, myh7, myl7, and myh6) and erythropoiesis-related genes (gata1a, hbbe1, hbbe2, and alas2) were disrupted after isoflucypram exposure. Furthermore, enrichment analysis indicated that most of the differentially expressed genes (DEGs) were enriched in heart development or hemopoiesis processes. Overall, these findings suggest that exposure to isoflucypram is associated with developmental and cardiovascular toxicity in zebrafish." @default.
- W3159351663 created "2021-05-10" @default.
- W3159351663 creator A5001162052 @default.
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- W3159351663 date "2021-09-01" @default.
- W3159351663 modified "2023-09-23" @default.
- W3159351663 title "Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio)" @default.
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- W3159351663 doi "https://doi.org/10.1016/j.scitotenv.2021.147529" @default.
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