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- W3159359941 abstract "Abstract Trypanosoma cruzi , the causative agent of Chagas disease, undergoes drastic morphological and biochemical modifications as it passes between hosts and transitions from extracellular to intracellular stages. The osmotic and mechanical aspects of these cellular transformations are not understood. Here we identify and characterize a novel mechanosensitive channel in T. cruzi (TcMscS) belonging to the superfamily of small conductance mechanosensitive channels (MscS). TcMscS is activated by membrane tension and forms a large pore permeable to anions, cations, and small osmolytes. The channel changes its location from the contractile vacuole complex in epimastigotes to the plasma membrane as the parasites develop into intracellular amastigotes. TcMscS knockout parasites show significant fitness defects, including increased cell volume, calcium dysregulation, impaired differentiation, and a dramatic decrease in infectivity. Our work provides mechanistic insights into components supporting pathogen adaptation inside the host thus opening the exploration of mechanosensation as a prerequisite of protozoan infectivity." @default.
- W3159359941 created "2021-05-10" @default.
- W3159359941 creator A5001454015 @default.
- W3159359941 creator A5020117277 @default.
- W3159359941 creator A5022994126 @default.
- W3159359941 creator A5023625545 @default.
- W3159359941 creator A5025673176 @default.
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- W3159359941 creator A5045448769 @default.
- W3159359941 creator A5053603996 @default.
- W3159359941 creator A5076045409 @default.
- W3159359941 creator A5076838323 @default.
- W3159359941 date "2018-12-17" @default.
- W3159359941 modified "2023-10-18" @default.
- W3159359941 title "A novel mechanosensitive channel controls osmoregulation, differentiation and infectivity in<i>Trypanosoma cruzi</i>" @default.
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