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- W3159431567 abstract "Prenatal cannabis use disorder (CUD) is associated with adverse infant health outcomes, and this association is exacerbated further among non-white mothers and those who use tobacco. Individual-, community- and health-care-level approaches are needed to educate and support pregnant women with CUD to improve perinatal health. In the population-based retrospective cohort study by Shi et al. investigating the association of impact of prenatal cannabis use disorder (CUD) and health outcomes among California-born infants [1], four important take-aways include: (1) the need for consistent and broad public health messaging about perinatal cannabis use and adverse outcomes; (2) uncertainty about the causes of infant mortality for this population; (3) perinatal tobacco exposure as a significant predictor of adverse outcomes; and (4) ongoing racial/ethnic disparities in perinatal outcomes. First, Shi et al. demonstrate that rates of prenatal SUD in California increased nearly threefold from 2001 to 2012. With legalization of marijuana across the United States, cannabis use has increased among the general population. However, this same upward trend among the pregnant population is concerning, given the results of this study as well as others [2-4] that highlight potential harm to the developing fetus and newborn. Maternal survey data recently reported that reasons for marijuana use included treatment for nausea, vomiting and stress [5, 6]. In fact, pregnant women receive mixed messages about the potential harm of prenatal cannabis use [7, 8]. Clearly, there is an urgent need for broad public health messaging emphasizing caution about prenatal cannabis use for health-care providers and patients that is clear and consistent across various sectors such as health, education, judicial and child welfare arenas. Secondly, Shi et al. report that prenatal CUD was associated with higher odds of infant mortality. This startling finding requires additional investigation to more clearly understand the causes of these deaths. As highlighted in their limitations section, Shi and his team were not able to further investigate the timing surrounding circumstances and precise causes of infant deaths. Infant mortality in the United States is highest of any developed country in the world, and the risk factors associated with infant death vary by infant characteristics such as prematurity and low birth weight [9, 10]. Moreover, causes of death vary for infants who die in the first month of life versus beyond this early neonatal period. For infants born to mothers with prenatal CUD, it is imperative that we understand if mortality is attributed to medical complexity or vulnerability seen during birth hospitalization versus factors that arise when the infant is months older. For instance, sudden unexpected infant death (SUID) is the leading cause of post-neonatal infant mortality in the United States, and most of these deaths are due to unsafe sleep practices such as suffocation due to sharing a sleep surface with an adult or from unsafe objects in the infants’ sleep areas [10, 11]. Parental substance use is an independent risk factor for SUID in the United States. Thus, if additional investigation of the deaths highlighted in the Shi et al. study demonstrate that unsafe sleep practices are identified, greater educational efforts that specifically target families with CUD will be needed, given the growing population of cannabis users in the United States. Thirdly, while the focus of this study was on prenatal CUD, in their subanalysis Shi et al. demonstrate that among women with prenatal CUD, mothers who also used tobacco during pregnancy had greater odds of delivering pre-term and having an infant who was low birth weight, needed hospitalization and died in the first year of life. As marijuana is legalized in more US states and the attention of public health and medical organizations focus upon cannabis use, we cannot lose sight of the well-established harm caused by perinatal tobacco use, which is much more widespread at present than cannabis use. The literature on prenatal cannabis use and perinatal health outcomes is still growing, but the evidence base for tobacco use and adverse infant health is robust in history and quality. Clinical providers, public health experts and policy-makers will need to target tobacco use as they also address the growing use of cannabis in the United States. Fourthly, unconscionable racial/ethnic disparities in perinatal health outcomes exist in the United States [12, 13]. These disparities are again highlighted by Shi et al. among women with CUD. They show that when compared to infants born to non-Hispanic white mothers, those born to Hispanic, non-Hispanic black and non-Hispanic other minorities had greater odds of adverse health outcomes. Thus, even among this subset of the general birthing population, racial/ethnic inequities are pervasive. As perinatal substance use disorders (SUD) have increased in the United States, there is a growing awareness of the experience of stigma and bias by birthing individuals with SUD. While data are lacking, one can hypothesize that these negative experiences are probably even worse for women and families of color. To support pregnant individuals, mothers, infants and families affected by CUD and other SUDs, health systems need to recognize these disparities and develop targeted strategies to understand the drivers of these disparities so that effective interventions can be developed to improve the health of mothers and infants, not only in aggregate, but also for specific racial/ethnic groups. S.H. reports no financial or other relevant links to companies with an interest in the topic of this article." @default.
- W3159431567 created "2021-05-10" @default.
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- W3159431567 date "2021-05-04" @default.
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- W3159431567 title "Commentary on Shi <i>et al</i> : Prenatal cannabis use and infant health ‐ the search for clarity and consistency" @default.
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- W3159431567 doi "https://doi.org/10.1111/add.15522" @default.
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