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- W3159455219 abstract "Previous studies have shown that calcium tungstate (CaWO4) nanoparticles (NPs) can be used as a radiosensitizing/X-ray contrast agent for cancer treatment. However, due to the propensity of calcium tungstate to agglomerate in physiological solutions, there is a need to encapsulate these NPs within poly(ethylene glycol)-poly(d,l-lactic acid) (PEG–PLA) polymeric micelles through a solvent exchange process. Several parameters including solvent type, polymer to NP ratio, mixing method, and lyophilization were studied to optimize the encapsulation and storage procedures for future scale-up. Herein, we report that the cosolvent that was previously used in this procedure (dimethylformamide) can be replaced with a less toxic cosolvent (acetone), the polymer to NP ratio can be reduced from 600:1 to 50:1 without increasing the particle size by 20%, and mixing methods that create a more uniform flow field produce a more homogenous and less polydisperse particle distribution. In addition, our results indicate that sucrose as a lyophilization excipient produces less agglomeration during freeze-drying compared to mannitol. The smaller molecular weight 2 kDa and 2 kDa (“2 k–2 k”) PEG–PLA was less prone to agglomeration during freeze-drying compared to 5 k–5 k PEG–PLA." @default.
- W3159455219 created "2021-05-10" @default.
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- W3159455219 date "2021-05-06" @default.
- W3159455219 modified "2023-09-23" @default.
- W3159455219 title "Pilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG–PLA Block Copolymer-Encapsulated CaWO<sub>4</sub> Radioluminescent Nanoparticles for Theranostic Applications" @default.
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- W3159455219 doi "https://doi.org/10.1021/acs.iecr.0c05852" @default.
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