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- W3159465173 abstract "Alternative splicing (AS) is fundamental to the diversity of transcriptome and proteome, and data from recently studies suggested a critical association between alternative splicing and oncogenic processes. To date there has been no systematic analysis on alternative splicing signature in different gender and subtype of non-small cell lung cancer. Thus, we integrated the information of NSCLC patients from The Cancer Genome Atlas (TCGA) and evaluated alternative splicing profiles from different gender and subtype perspectives. Eventually, a total of 3357 and 1983 AS events were found significant related to overall survival of LUAD and LUSC patients. Four prognostic prediction models performed well in 1-,3-,5-years, with the area under the curve (AUC) of receiver operating characteristic (ROC) curves great than 0.900. Notably, splicing interaction network revealed an obvious regulatory pattern by which splicing factors (SF) regulate AS events.Funding Statement: This work was supported by research supervisor Xiaochun Zhang.Declaration of Interests: The authors declare that they have no competing interests.Ethics Approval Statement: Not required." @default.
- W3159465173 created "2021-05-10" @default.
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- W3159465173 date "2019-01-01" @default.
- W3159465173 modified "2023-09-22" @default.
- W3159465173 title "Survival-Associated Alternative Splicing Signatures in Non-Small Cell Lung Cancer" @default.
- W3159465173 doi "https://doi.org/10.2139/ssrn.3417860" @default.
- W3159465173 hasPublicationYear "2019" @default.
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