FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159489040> ?p ?o ?g. }

• W3159489040 abstract "Abstract Background Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Results In total, 56 mucosal microbiome samples were collected from 28 Chinese UC patients and their healthy family partners, followed by amplicon sequencing. Based on sequencing data, we analyzed species diversity, shared species, and inter-species interactions at the whole community, main phyla, and core/periphery species levels. We identified four opportunistic “pathogens” (i.e., Clostridium tertium , Odoribacter splanchnicus , Ruminococcus gnavus , and Flavonifractor plautii ) with potential significance for the diagnosis and treatment of UC, which were inhibited in healthy individuals, but unrestricted in the UC patients. In addition, we also discovered in this study: ( i ) The positive-to-negative links (P/N) ratio, which measures the balance of species interactions or inhibition effects in microbiome networks, was significantly higher in UC patients, indicating loss of inhibition against potentially opportunistic “pathogens” associated with dysbiosis. ( ii ) Previous studies have reported conflicting evidence regarding species diversity and composition between UC patients and healthy controls. Here, significant differences were found at the major phylum and core/periphery scales, but not at the whole community level. Thus, we argue that the paradoxical results found in existing studies are due to the scale effect. Conclusions Our results reveal changes in the ecology and network structure of the gut mucosal microbiome that might be associated with UC, and these changes might provide potential therapeutic mechanisms of UC. The four opportunistic pathogens that were identified in the present study deserve further investigation in future studies." @default.
• W3159489040 created "2021-05-10" @default.
• W3159489040 creator A5017426085 @default.
• W3159489040 creator A5028207824 @default.
• W3159489040 creator A5028859676 @default.
• W3159489040 creator A5029818365 @default.
• W3159489040 creator A5032612435 @default.
• W3159489040 creator A5035175414 @default.
• W3159489040 creator A5036723452 @default.
• W3159489040 creator A5044437474 @default.
• W3159489040 creator A5055842287 @default.
• W3159489040 creator A5062973831 @default.
• W3159489040 creator A5067153841 @default.
• W3159489040 creator A5068595169 @default.
• W3159489040 creator A5068877066 @default.
• W3159489040 creator A5069449318 @default.
• W3159489040 creator A5086582675 @default.
• W3159489040 date "2021-05-04" @default.
• W3159489040 modified "2023-10-01" @default.
• W3159489040 title "Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)" @default.
• W3159489040 cites W1523559518 @default.
• W3159489040 cites W1903347368 @default.
• W3159489040 cites W1983728610 @default.
• W3159489040 cites W2006802554 @default.
• W3159489040 cites W2022825068 @default.
• W3159489040 cites W2029500193 @default.
• W3159489040 cites W2038133823 @default.
• W3159489040 cites W2042757610 @default.
• W3159489040 cites W2047119586 @default.
• W3159489040 cites W2047208232 @default.
• W3159489040 cites W2062237052 @default.
• W3159489040 cites W2072401296 @default.
• W3159489040 cites W2072688741 @default.
• W3159489040 cites W2076829601 @default.
• W3159489040 cites W2078212357 @default.
• W3159489040 cites W2085847362 @default.
• W3159489040 cites W2088608269 @default.
• W3159489040 cites W2088833470 @default.
• W3159489040 cites W2103459268 @default.
• W3159489040 cites W2103600425 @default.
• W3159489040 cites W2105190780 @default.
• W3159489040 cites W2107805776 @default.
• W3159489040 cites W2116439669 @default.
• W3159489040 cites W2124418252 @default.
• W3159489040 cites W2129994723 @default.
• W3159489040 cites W2132371343 @default.
• W3159489040 cites W2135787796 @default.
• W3159489040 cites W2136850043 @default.
• W3159489040 cites W2141034720 @default.
• W3159489040 cites W2143777796 @default.
• W3159489040 cites W2149981091 @default.
• W3159489040 cites W2152751713 @default.
• W3159489040 cites W2159675211 @default.
• W3159489040 cites W2282772932 @default.
• W3159489040 cites W2320977646 @default.
• W3159489040 cites W2400270113 @default.
• W3159489040 cites W2441567471 @default.
• W3159489040 cites W2512607448 @default.
• W3159489040 cites W2554466792 @default.
• W3159489040 cites W2588997555 @default.
• W3159489040 cites W2736839127 @default.
• W3159489040 cites W2752700535 @default.
• W3159489040 cites W2755706695 @default.
• W3159489040 cites W2761654301 @default.
• W3159489040 cites W2761699854 @default.
• W3159489040 cites W2769664962 @default.
• W3159489040 cites W2778416039 @default.
• W3159489040 cites W2885920472 @default.
• W3159489040 cites W2903406988 @default.
• W3159489040 cites W2912939143 @default.
• W3159489040 cites W2921173578 @default.
• W3159489040 cites W2922074178 @default.
• W3159489040 cites W2923867259 @default.
• W3159489040 cites W2937665099 @default.
• W3159489040 cites W2944986981 @default.
• W3159489040 cites W2947189704 @default.
• W3159489040 cites W2947879944 @default.
• W3159489040 cites W2951518977 @default.
• W3159489040 cites W2981077407 @default.
• W3159489040 cites W2982041933 @default.
• W3159489040 cites W3101528479 @default.
• W3159489040 doi "https://doi.org/10.1186/s12866-021-02201-6" @default.
• W3159489040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8097971" @default.
• W3159489040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33947329" @default.
• W3159489040 hasPublicationYear "2021" @default.
• W3159489040 type Work @default.
• W3159489040 sameAs 3159489040 @default.
• W3159489040 citedByCount "21" @default.
• W3159489040 countsByYear W31594890402021 @default.
• W3159489040 countsByYear W31594890402022 @default.
• W3159489040 countsByYear W31594890402023 @default.
• W3159489040 crossrefType "journal-article" @default.
• W3159489040 hasAuthorship W3159489040A5017426085 @default.
• W3159489040 hasAuthorship W3159489040A5028207824 @default.
• W3159489040 hasAuthorship W3159489040A5028859676 @default.
• W3159489040 hasAuthorship W3159489040A5029818365 @default.
• W3159489040 hasAuthorship W3159489040A5032612435 @default.
• W3159489040 hasAuthorship W3159489040A5035175414 @default.
• W3159489040 hasAuthorship W3159489040A5036723452 @default.
• W3159489040 hasAuthorship W3159489040A5044437474 @default.

• next