FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159518564> ?p ?o ?g. }

• W3159518564 endingPage "112300" @default.
• W3159518564 startingPage "112300" @default.
• W3159518564 abstract "In recent years, frequent hexavalent chromium [Cr(VI)] pollution incidents have severely damaged the ecology and endangered the public health. It is well known that cell senescence could promote the carcinogenesis, thus the related research on the occurrence of premature senescence is of great significance to the elucidation of the carcinogenic mechanism of Cr(VI). We previously confirmed that long-term low-dose Cr(VI) exposure induced premature senescence, but the key molecular events that determine the occurrence of premature senescence are still unclear. In the present study, we found that Cr(VI) induced phosphorylation of dynamin-relatedprotein 1 (Drp1)-S637 site in premature senescent cells, which was accompanied with the decrease of mitochondrial fission. We also demonstrated that the phosphorylation status of Drp1-S637 after Cr(VI) exposure was related to the antagonism of PKA/PP2B, and continuous dephosphorylation of Drp1-S637 attenuated premature senescence caused by Cr(VI). The epidermal growth factor receptor (EGFR) overexpression significantly alleviated the occurrence of premature senescence, and the expressions of EFGR and its downstream molecules were related to the phosphorylation status of Drp1-S637. In brief, we revealed the role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence. This study is the first time to link the phosphorylation of Drp1 with Cr(VI)-induced premature senescence, in order to find the key molecular events that determine the occurrence of premature senescence and demonstrate the molecular mechanism of abnormal elongated mitochondria formation in the senescence process. The significance of this study is to explore the carcinogenesis of Cr(VI) and provide new ideas and strategies for the targeted treatment of Cr(VI)-related cancers." @default.
• W3159518564 created "2021-05-10" @default.
• W3159518564 creator A5014973946 @default.
• W3159518564 creator A5036826155 @default.
• W3159518564 creator A5052835939 @default.
• W3159518564 creator A5054775711 @default.
• W3159518564 creator A5058837840 @default.
• W3159518564 creator A5067678021 @default.
• W3159518564 date "2021-07-01" @default.
• W3159518564 modified "2023-09-27" @default.
• W3159518564 title "The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence" @default.
• W3159518564 cites W1542666708 @default.
• W3159518564 cites W2002285262 @default.
• W3159518564 cites W2009547397 @default.
• W3159518564 cites W2033885016 @default.
• W3159518564 cites W2034392492 @default.
• W3159518564 cites W2047772062 @default.
• W3159518564 cites W2056982404 @default.
• W3159518564 cites W2088047336 @default.
• W3159518564 cites W2095368496 @default.
• W3159518564 cites W2099361886 @default.
• W3159518564 cites W2104653462 @default.
• W3159518564 cites W2123795043 @default.
• W3159518564 cites W2125302529 @default.
• W3159518564 cites W2135537747 @default.
• W3159518564 cites W2152877666 @default.
• W3159518564 cites W2273828757 @default.
• W3159518564 cites W2287768527 @default.
• W3159518564 cites W2495582206 @default.
• W3159518564 cites W2529792485 @default.
• W3159518564 cites W2557985312 @default.
• W3159518564 cites W2591731427 @default.
• W3159518564 cites W2792317071 @default.
• W3159518564 cites W2793755148 @default.
• W3159518564 cites W2897924263 @default.
• W3159518564 cites W2904511486 @default.
• W3159518564 cites W2954445592 @default.
• W3159518564 cites W2969424312 @default.
• W3159518564 cites W2973434555 @default.
• W3159518564 cites W2981003114 @default.
• W3159518564 cites W3023805943 @default.
• W3159518564 cites W3036497998 @default.
• W3159518564 cites W3043700907 @default.
• W3159518564 cites W3086640517 @default.
• W3159518564 cites W3094472830 @default.
• W3159518564 cites W3111265170 @default.
• W3159518564 cites W3130048701 @default.
• W3159518564 doi "https://doi.org/10.1016/j.ecoenv.2021.112300" @default.
• W3159518564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33971394" @default.
• W3159518564 hasPublicationYear "2021" @default.
• W3159518564 type Work @default.
• W3159518564 sameAs 3159518564 @default.
• W3159518564 citedByCount "3" @default.
• W3159518564 countsByYear W31595185642022 @default.
• W3159518564 countsByYear W31595185642023 @default.
• W3159518564 crossrefType "journal-article" @default.
• W3159518564 hasAuthorship W3159518564A5014973946 @default.
• W3159518564 hasAuthorship W3159518564A5036826155 @default.
• W3159518564 hasAuthorship W3159518564A5052835939 @default.
• W3159518564 hasAuthorship W3159518564A5054775711 @default.
• W3159518564 hasAuthorship W3159518564A5058837840 @default.
• W3159518564 hasAuthorship W3159518564A5067678021 @default.
• W3159518564 hasBestOaLocation W31595185641 @default.
• W3159518564 hasConcept C11960822 @default.
• W3159518564 hasConcept C121608353 @default.
• W3159518564 hasConcept C143425029 @default.
• W3159518564 hasConcept C17619807 @default.
• W3159518564 hasConcept C178666793 @default.
• W3159518564 hasConcept C181912034 @default.
• W3159518564 hasConcept C185592680 @default.
• W3159518564 hasConcept C28859421 @default.
• W3159518564 hasConcept C2909947164 @default.
• W3159518564 hasConcept C502942594 @default.
• W3159518564 hasConcept C522857546 @default.
• W3159518564 hasConcept C54355233 @default.
• W3159518564 hasConcept C552990157 @default.
• W3159518564 hasConcept C55493867 @default.
• W3159518564 hasConcept C555283112 @default.
• W3159518564 hasConcept C86803240 @default.
• W3159518564 hasConcept C95444343 @default.
• W3159518564 hasConceptScore W3159518564C11960822 @default.
• W3159518564 hasConceptScore W3159518564C121608353 @default.
• W3159518564 hasConceptScore W3159518564C143425029 @default.
• W3159518564 hasConceptScore W3159518564C17619807 @default.
• W3159518564 hasConceptScore W3159518564C178666793 @default.
• W3159518564 hasConceptScore W3159518564C181912034 @default.
• W3159518564 hasConceptScore W3159518564C185592680 @default.
• W3159518564 hasConceptScore W3159518564C28859421 @default.
• W3159518564 hasConceptScore W3159518564C2909947164 @default.
• W3159518564 hasConceptScore W3159518564C502942594 @default.
• W3159518564 hasConceptScore W3159518564C522857546 @default.
• W3159518564 hasConceptScore W3159518564C54355233 @default.
• W3159518564 hasConceptScore W3159518564C552990157 @default.
• W3159518564 hasConceptScore W3159518564C55493867 @default.
• W3159518564 hasConceptScore W3159518564C555283112 @default.
• W3159518564 hasConceptScore W3159518564C86803240 @default.
• W3159518564 hasConceptScore W3159518564C95444343 @default.
• W3159518564 hasFunder F4320321001 @default.

• next