FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159592209> ?p ?o ?g. }

• W3159592209 abstract "Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF has been implicated in the mechanism of action of ketamine, a N-methyl- d -aspartic acid receptor (NMDAR) antagonist with rapid anti-depressant effects in humans. REL-1017 (esmethadone), the d-optical isomer of the racemic mixture d- l -methadone, is devoid of clinically relevant opioid activity at doses expected to exert therapeutic NMDAR antagonistic activity in humans. The present study was conducted to ascertain the effects of oral administration of 25 mg of REL-1017 for 10 days on plasma BDNF in healthy subjects confined to an inpatient unit for a phase 1 clinical trial. We observed an increase in post-treatment BDNF plasma levels compared to pre-treatment levels. Post-treatment, Day 10 BDNF plasma levels ranged from 2 to 17 times pre-treatment levels in the 25 mg REL-1017 treatment group, whereas in the placebo group, BDNF plasma levels remained unchanged ( p = 0.028). Diastolic blood pressure decreased significantly in subjects treated with REL-1017, while no effect could be observed in the placebo group. In conclusion, the administration of 25 mg REL-1017 significantly increased BDNF plasma levels and significantly decreased diastolic blood pressure in healthy subjects confined to an inpatient unit for a phase 1 clinical trial." @default.
• W3159592209 created "2021-05-10" @default.
• W3159592209 creator A5004302186 @default.
• W3159592209 creator A5015501263 @default.
• W3159592209 creator A5016785133 @default.
• W3159592209 creator A5017874146 @default.
• W3159592209 creator A5025926000 @default.
• W3159592209 creator A5027968457 @default.
• W3159592209 creator A5028314110 @default.
• W3159592209 creator A5053802958 @default.
• W3159592209 creator A5057781578 @default.
• W3159592209 creator A5059921142 @default.
• W3159592209 creator A5067118176 @default.
• W3159592209 date "2021-04-28" @default.
• W3159592209 modified "2023-10-01" @default.
• W3159592209 title "REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study" @default.
• W3159592209 cites W1981097208 @default.
• W3159592209 cites W1997962734 @default.
• W3159592209 cites W2010721082 @default.
• W3159592209 cites W2037595197 @default.
• W3159592209 cites W2065890869 @default.
• W3159592209 cites W2076507733 @default.
• W3159592209 cites W2089351762 @default.
• W3159592209 cites W2094166526 @default.
• W3159592209 cites W2094957254 @default.
• W3159592209 cites W2111078070 @default.
• W3159592209 cites W2152644978 @default.
• W3159592209 cites W2167565363 @default.
• W3159592209 cites W2581839563 @default.
• W3159592209 cites W2614646876 @default.
• W3159592209 cites W2737005305 @default.
• W3159592209 cites W2800406500 @default.
• W3159592209 cites W2807083575 @default.
• W3159592209 cites W2925451033 @default.
• W3159592209 cites W2959816154 @default.
• W3159592209 cites W2963936193 @default.
• W3159592209 cites W2965954447 @default.
• W3159592209 cites W2970683278 @default.
• W3159592209 cites W3017406288 @default.
• W3159592209 doi "https://doi.org/10.3389/fphar.2021.671859" @default.
• W3159592209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8113752" @default.
• W3159592209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995104" @default.
• W3159592209 hasPublicationYear "2021" @default.
• W3159592209 type Work @default.
• W3159592209 sameAs 3159592209 @default.
• W3159592209 citedByCount "15" @default.
• W3159592209 countsByYear W31595922092022 @default.
• W3159592209 countsByYear W31595922092023 @default.
• W3159592209 crossrefType "journal-article" @default.
• W3159592209 hasAuthorship W3159592209A5004302186 @default.
• W3159592209 hasAuthorship W3159592209A5015501263 @default.
• W3159592209 hasAuthorship W3159592209A5016785133 @default.
• W3159592209 hasAuthorship W3159592209A5017874146 @default.
• W3159592209 hasAuthorship W3159592209A5025926000 @default.
• W3159592209 hasAuthorship W3159592209A5027968457 @default.
• W3159592209 hasAuthorship W3159592209A5028314110 @default.
• W3159592209 hasAuthorship W3159592209A5053802958 @default.
• W3159592209 hasAuthorship W3159592209A5057781578 @default.
• W3159592209 hasAuthorship W3159592209A5059921142 @default.
• W3159592209 hasAuthorship W3159592209A5067118176 @default.
• W3159592209 hasBestOaLocation W31595922091 @default.
• W3159592209 hasConcept C126322002 @default.
• W3159592209 hasConcept C134018914 @default.
• W3159592209 hasConcept C142724271 @default.
• W3159592209 hasConcept C160539049 @default.
• W3159592209 hasConcept C170493617 @default.
• W3159592209 hasConcept C204787440 @default.
• W3159592209 hasConcept C27081682 @default.
• W3159592209 hasConcept C2776885963 @default.
• W3159592209 hasConcept C2778790584 @default.
• W3159592209 hasConcept C67018056 @default.
• W3159592209 hasConcept C71924100 @default.
• W3159592209 hasConcept C84393581 @default.
• W3159592209 hasConcept C98274493 @default.
• W3159592209 hasConceptScore W3159592209C126322002 @default.
• W3159592209 hasConceptScore W3159592209C134018914 @default.
• W3159592209 hasConceptScore W3159592209C142724271 @default.
• W3159592209 hasConceptScore W3159592209C160539049 @default.
• W3159592209 hasConceptScore W3159592209C170493617 @default.
• W3159592209 hasConceptScore W3159592209C204787440 @default.
• W3159592209 hasConceptScore W3159592209C27081682 @default.
• W3159592209 hasConceptScore W3159592209C2776885963 @default.
• W3159592209 hasConceptScore W3159592209C2778790584 @default.
• W3159592209 hasConceptScore W3159592209C67018056 @default.
• W3159592209 hasConceptScore W3159592209C71924100 @default.
• W3159592209 hasConceptScore W3159592209C84393581 @default.
• W3159592209 hasConceptScore W3159592209C98274493 @default.
• W3159592209 hasLocation W31595922091 @default.
• W3159592209 hasLocation W31595922092 @default.
• W3159592209 hasLocation W31595922093 @default.
• W3159592209 hasLocation W31595922094 @default.
• W3159592209 hasOpenAccess W3159592209 @default.
• W3159592209 hasPrimaryLocation W31595922091 @default.
• W3159592209 hasRelatedWork W2019185608 @default.
• W3159592209 hasRelatedWork W2020924852 @default.
• W3159592209 hasRelatedWork W2025705614 @default.
• W3159592209 hasRelatedWork W2036117787 @default.
• W3159592209 hasRelatedWork W2051270818 @default.
• W3159592209 hasRelatedWork W2065667368 @default.
• W3159592209 hasRelatedWork W2086317124 @default.

• next