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- W3159600144 abstract "Signal pathway inhibition is a well-validated approach for treating cancers driven by activated kinases such as KIT. However, kinase inhibitors may make tumor cells less responsive to tumor immune surveillance and less sensitive to immunotherapies. In this issue, Liu and colleagues report that, in a mouse model, inhibition of oncogenic KIT in gastrointestinal stromal tumors reduces type I interferon (IFN) production and signaling, and the effectiveness of the immune system in controlling tumor growth. They were able to partially overcome the immunosuppressive effects of KIT inhibition using agonists of the type I IFN response, pointing the way toward intelligently combining kinase inhibitors and immune modulators for therapy.See article by Liu et al., p. 542" @default.
- W3159600144 created "2021-05-10" @default.
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- W3159600144 date "2021-05-01" @default.
- W3159600144 modified "2023-10-16" @default.
- W3159600144 title "Reversing Imatinib's Immunosuppressive Effects by Modulating Type I IFN Signaling" @default.
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- W3159600144 doi "https://doi.org/10.1158/2326-6066.cir-21-0177" @default.
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