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• W3159602776 abstract "The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via the mouse double minute 2 homolog (MDM2) ubiquitin ligase. In synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein." @default.
• W3159602776 created "2021-05-10" @default.
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• W3159602776 date "2021-04-25" @default.
• W3159602776 modified "2023-10-12" @default.
• W3159602776 title "HDAC2 links ubiquitination to tumor suppression in synovial sarcoma" @default.
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• W3159602776 doi "https://doi.org/10.1080/23723556.2021.1914291" @default.
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